Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Transient receptor potential cation channel subfamily A member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.0133 | 0.4375 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0218 | 0.9469 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0227 | 1 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0073 | 0.0783 | 0.1537 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0.1594 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.1501 | 0.1894 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0.1594 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0227 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0196 | 0.8179 | 0.1635 |
Plasmodium vivax | peptide deformylase, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0118 | 0.3518 | 0.4438 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0196 | 0.8161 | 0.152 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0145 | 0.5094 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1594 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0227 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1594 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0133 | 0.4375 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0.1594 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0118 | 0.3518 | 0.4438 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0783 | 0.1537 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0218 | 0.9469 | 1 |
Brugia malayi | Matrixin family protein | 0.0145 | 0.5094 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0133 | 0.4375 | 0.859 |
Onchocerca volvulus | 0.0085 | 0.1501 | 0.3431 | |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0.1594 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0227 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0227 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0.1594 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0227 | 1 | 1 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0192 | 0.7927 | 1 |
Brugia malayi | Hemopexin family protein | 0.0085 | 0.1501 | 0.2947 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 4.09 uM | Agonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as increase in allyl isothiocyanate-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis | ChEMBL. | 23206861 |
EC50 (binding) | = 6.42 uM | Agonist activity at human TRPV1 overexpressed in HEK293 cells assessed as increase in ionomycin-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis | ChEMBL. | 23206861 |
Efficacy (binding) | = 49 % | Agonist activity at human TRPV1 overexpressed in HEK293 cells assessed as increase in ionomycin-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control | ChEMBL. | 23206861 |
Efficacy (binding) | = 83.5 % | Agonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as increase in allyl isothiocyanate-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control | ChEMBL. | 23206861 |
IC50 (binding) | = 3.13 uM | Antagonist activity at human TRPV1 overexpressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level incubated for 5 mins prior to capsaicin addition by Fluo-4 based spectrofluorimetric analysis | ChEMBL. | 23206861 |
IC50 (binding) | = 12.9 uM | Antagonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ level incubated for 5 mins prior to allyl isothiocyanate addition by Fluo-4 based spectrofluorimetric analysis | ChEMBL. | 23206861 |
IC50 (binding) | > 50 uM | Inhibition of FAAH in rat brain homogenates using [14C]anandamide as substrate assessed as formation of [14C]ethanolamine after 30 mins by scintillation counting analysis | ChEMBL. | 23206861 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.