Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Cardioprotective activity in mouse overexpressing clasequestrin assessed as increase in LV posterior wall thickness during diastole at 10 uM, sc administered as infusion for 2 weeks relative to control | ChEMBL. | 23286881 | |
Activity (functional) | Cardioprotective activity in BL6 mouse LAD ligation ischemic heart failure model assessed as change in infarct size at 10 uM, sc administered as infusion at 24 hrs post-LAD ligation for 1 month relative to control | ChEMBL. | 23286881 | |
Activity (functional) | Cardioprotective activity in mouse overexpressing clasequestrin assessed as increase in LV posterior wall thickness during systole at 10 uM, sc administered as infusion for 2 weeks relative to control | ChEMBL. | 23286881 | |
Activity (functional) | Cardioprotective activity in mouse overexpressing clasequestrin assessed as increase in LV septal wall thickness during systole at 10 uM, sc administered as infusion for 2 weeks relative to control | ChEMBL. | 23286881 | |
Activity (functional) | Cardioprotective activity in BL6 mouse LAD ligation ischemic heart failure model assessed as fractional shortening at 10 uM, sc administered as infusion at 24 hrs post LAD ligation for 28 days by echocardiography (Rvb = 17.33 +/- 1.36%) | ChEMBL. | 23286881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.