Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.1929 | 1 | 1 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1929 | 1 | 1 |
Chlamydia trachomatis | glutamate symporter | 0.1929 | 1 | 1 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.1929 | 1 | 0.5 |
Treponema pallidum | glutamate/aspartate transporter | 0.0855 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.1929 | 1 | 0.5 |
Echinococcus granulosus | neutral amino acid transporter | 0.1929 | 1 | 0.5 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.1929 | 1 | 1 |
Toxoplasma gondii | subtilisin SUB9 | 0.0992 | 0.1274 | 0.5 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.1929 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.1929 | 1 | 1 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.1929 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1929 | 1 | 1 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.1929 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.1929 | 1 | 0.5 |
Echinococcus granulosus | neutral amino acid transporter A | 0.1929 | 1 | 0.5 |
Treponema pallidum | glutamate transporter | 0.0855 | 0 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.1929 | 1 | 0.5 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.1929 | 1 | 1 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.1929 | 1 | 1 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.1929 | 1 | 1 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.1929 | 1 | 1 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.1929 | 1 | 0.5 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.1929 | 1 | 0.5 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.1929 | 1 | 0.5 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.1929 | 1 | 1 |
Echinococcus granulosus | neutral amino acid transporter A | 0.1929 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1929 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | >> 100 ug ml-1 | Tested for cytotoxicity against antigen negative T-24 bladder carcinoma cells having only 3-5% antigen expression; <20% inhibition achieved | ChEMBL. | 8496926 |
IC50 (functional) | >> 300 uM | Tested for cytotoxicity against antigen negative T-24 bladder carcinoma cells having only 3-5% antigen expression; <20% inhibition achieved | ChEMBL. | 8496926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.