Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0251 | 0.3716 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0184 | 0.2171 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0184 | 0.2171 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0089 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0184 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2128 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2128 | 0.2128 |
Plasmodium falciparum | protein kinase 5 | 0.0089 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0089 | 0 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0184 | 0.2171 | 1 |
Echinococcus granulosus | dual specificity | 0.0184 | 0.2171 | 0.2171 |
Echinococcus multilocularis | dual specificity | 0.0184 | 0.2171 | 0.2171 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.2171 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0184 | 0.2171 | 0.2171 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0184 | 0.2171 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0184 | 0.2171 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.3716 | 0.3716 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0184 | 0.2171 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0184 | 0.2171 | 0.5843 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.3716 | 0.3716 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0525 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0184 | 0.2171 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0525 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0089 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0525 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0089 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0089 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.