TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 743.868 | Formula: C40H51N6O8+
H donors: 6 H acceptors: 8 LogP: 1.7 Rotable bonds: 22
Rule of 5 violations (Lipinski): 3
SMILES: CC(C[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N1CCC[C@H]1C(=O)c1ccc[n+](c1)C)Cc1ccc(cc1)O)C)C
InChi: 1S/C40H50N6O8/c1-25(2)20-32(40(53)54)44-38(51)31(21-27-10-6-5-7-11-27)43-35(48)23-41-37(50)26(3)42-39(52)34(22-28-14-16-30(47)17-15-28)46-19-9-13-33(46)36(49)29-12-8-18-45(4)24-29/h5-8,10-12,14-18,24-26,31-34H,9,13,19-23H2,1-4H3,(H5-,41,42,43,44,47,48,50,51,52,53,54)/p+1/t26-,31-,32-,33-,34-/m0/s1
InChiKey: MWDFWOBDTDVXTP-NQBDWGITSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Onchocerca volvulus		0.0602	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0237	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0237	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0237	0	0.5
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0244	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus multilocularis	SH2 motif	0.0365	0.352	0.352
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0365	0.352	0.352
Echinococcus multilocularis	NCK adaptor protein	0.0365	0.352	0.352
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0365	0.352	0.352
Loa Loa (eye worm)	SH2 domain-containing protein	0.0365	0.352	0.352
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0237	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0365	0.352	0.352
Onchocerca volvulus		0.0602	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0237	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0237	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0365	0.352	0.352
Brugia malayi	Tyrosine-protein kinase abl-1	0.0602	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0602	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0365	0.352	0.352
Giardia lamblia	Kinase, NEK	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0365	0.352	0.352
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0365	0.352	0.352
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Echinococcus granulosus	c src tyrosine kinase	0.0602	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0365	0.352	0.352
Loa Loa (eye worm)	TK protein kinase	0.0602	1	1
Loa Loa (eye worm)	STAT protein	0.0365	0.352	0.352
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0237	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Schistosoma mansoni	tensin-related	0.0365	0.352	0.352
Schistosoma mansoni	tensin	0.0365	0.352	0.352
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0365	0.352	0.352
Plasmodium vivax	protein kinase, putative	0.0237	0	0.5
Toxoplasma gondii	protein kinase	0.0237	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0243	0.017	0.017
Echinococcus multilocularis	tyrosine protein kinase shark	0.0602	1	1
Trichomonas vaginalis	STE family protein kinase	0.0237	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0365	0.352	0.352
Schistosoma mansoni	protein kinase	0.0243	0.017	0.017
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.025	0.0374	0.0374
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0602	1	1
Onchocerca volvulus		0.0602	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0602	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine kinase	0.0602	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0602	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0243	0.017	0.017
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0365	0.352	0.352
Onchocerca volvulus		0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	SRC-1	0.0602	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0602	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine kinase	0.0243	0.017	0.017
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0602	1	1
Plasmodium falciparum	protein kinase, putative	0.0237	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0365	0.352	0.352
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Brugia malayi	RhoGAP domain containing protein	0.0365	0.352	0.352
Loa Loa (eye worm)	SRC-1	0.0602	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0602	1	1
Echinococcus granulosus	NCK adaptor protein	0.0365	0.352	0.352
Brugia malayi	SH2 domain containing protein	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0237	0	0.5
Schistosoma mansoni	SH2A	0.0365	0.352	0.352
Entamoeba histolytica	SH2 domain containing protein	0.0365	0.352	0.352
Schistosoma mansoni	nck2/grb4	0.0365	0.352	0.352
Echinococcus multilocularis		0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0602	1	1
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Echinococcus multilocularis	tyrosine kinase	0.0602	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0365	0.352	0.352
Trypanosoma brucei	protein kinase, putative	0.0237	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Schistosoma mansoni	tensin	0.0365	0.352	0.352
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0365	0.352	0.352
Leishmania major	protein kinase, putative	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Onchocerca volvulus		0.0243	0.017	0.017
Brugia malayi	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine kinase	0.0243	0.017	0.017
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0365	0.352	0.352
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0237	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0602	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0365	0.352	0.352
Trichomonas vaginalis	protein kinase atn1, putative	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Giardia lamblia	Protein 21.1	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Leishmania major	protein kinase, putative	0.0237	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0602	1	1
Echinococcus granulosus	SH2 motif	0.0365	0.352	0.352
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0365	0.352	0.352
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0243	0.017	0.017
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0602	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0243	0.017	0.017
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0365	0.352	0.352
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0602	1	1
Schistosoma mansoni	tyrosine kinase	0.0243	0.017	0.017
Schistosoma mansoni	suppressor of cytokine signaling	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Brugia malayi	Protein kinase domain containing protein	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0243	0.017	0.017
Plasmodium falciparum	tyrosine kinase-like protein	0.0237	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0602	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0365	0.352	0.352
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0365	0.352	0.352
Onchocerca volvulus		0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0237	0	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0243	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0602	1	1
Toxoplasma gondii	STE kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0243	0.017	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0602	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0602	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0365	0.352	0.352
Giardia lamblia	Kinase, NEK	0.0237	0	0.5
Echinococcus multilocularis	tensin	0.0365	0.352	0.352
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0365	0.352	0.352
Echinococcus granulosus	expressed conserved protein	0.0365	0.352	0.352
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0237	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	hypothetical protein	0.0602	1	1
Trypanosoma brucei	Pseudokinase, putative	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Onchocerca volvulus		0.0365	0.352	0.352
Echinococcus multilocularis	SH2 motif	0.0365	0.352	0.352
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Schistosoma mansoni	vav2	0.0365	0.352	0.352
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0243	0.017	0.017
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tensin	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Onchocerca volvulus		0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0602	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0243	0.017	0.017
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0237	0	0.5
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Echinococcus granulosus	hypothetical protein	0.0365	0.352	0.352
Onchocerca volvulus		0.0365	0.352	0.352
Echinococcus multilocularis	SHC transforming protein 3	0.0365	0.352	0.352
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0602	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0237	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0243	0.017	0.017
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Giardia lamblia	Kinase	0.0237	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Brugia malayi	Protein kinase domain containing protein	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Schistosoma mansoni	suppressor of cytokine signaling	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus multilocularis	N chimaerin	0.0365	0.352	0.352
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0365	0.352	0.352
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0237	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0602	1	1
Schistosoma mansoni	hypothetical protein	0.0365	0.352	0.352
Brugia malayi	Variant SH3 domain containing protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0602	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0237	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0365	0.352	0.352
Brugia malayi	Variant SH3 domain containing protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0602	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Onchocerca volvulus		0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0237	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0602	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0365	0.352	0.352
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0237	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0602	1	1
Schistosoma mansoni	shc transforming protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0602	1	1
Plasmodium falciparum	protein kinase, putative	0.0237	0	0.5
Echinococcus multilocularis	tensin	0.0365	0.352	0.352
Loa Loa (eye worm)	SH2 domain-containing protein	0.0365	0.352	0.352
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Onchocerca volvulus		0.0365	0.352	0.352
Brugia malayi	protein-tyrosine kinase	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0365	0.352	0.352
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	N chimaerin	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0602	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0602	1	1
Echinococcus granulosus	SH2 motif	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0365	0.352	0.352
Echinococcus granulosus	SHC transforming protein 3	0.0365	0.352	0.352
Schistosoma mansoni	tensin-related	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	Tensin	0.0365	0.352	0.352
Schistosoma mansoni	adapter molecule crk	0.0365	0.352	0.352
Echinococcus multilocularis	SH2 domain containing protein 7	0.0365	0.352	0.352
Echinococcus granulosus	tyrosine kinase	0.0602	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0602	1	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0365	0.352	0.352
Schistosoma mansoni	tyrosine kinase	0.0602	1	1
Brugia malayi	SH2 domain containing protein	0.0602	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0237	0	0.5
Onchocerca volvulus		0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0602	1	1
Schistosoma mansoni	tensin	0.0365	0.352	0.352
Schistosoma mansoni	hypothetical protein	0.0365	0.352	0.352
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0602	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0365	0.352	0.352
Echinococcus granulosus	SH2 domain containing protein 7	0.0365	0.352	0.352
Echinococcus multilocularis	SH2 motif	0.0365	0.352	0.352
Leishmania major	hypothetical protein, conserved	0.0237	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Brugia malayi	SH2 domain containing protein	0.0365	0.352	0.352
Trichomonas vaginalis	TKL family protein kinase	0.0237	0	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0602	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0365	0.352	0.352
Loa Loa (eye worm)	hypothetical protein	0.0602	1	1
Onchocerca volvulus		0.0365	0.352	0.352

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2370936

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1743146