Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2386 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2386 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2386 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2386 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0932 | 0.1976 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0932 | 0.1976 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2386 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2386 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2386 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2386 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2386 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2386 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2386 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0932 | 0.1976 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0932 | 0.1976 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Paw swelling (functional) | = 100 % | Extent of paw swelling after treatment with thymopentin-5 (TP-5) compound in the Mouse Type II collagen arthritis at a dosage of 1.0 mg/kg on day 44 | ChEMBL. | 9240355 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.