Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.2641 | 0.3037 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.2641 | 0.3037 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.4809 | 0.5799 | 0.8291 |
Loa Loa (eye worm) | hypothetical protein | 0.2641 | 0.3037 | 0.4067 |
Loa Loa (eye worm) | matrixin family protein | 0.5467 | 0.6636 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.2641 | 0.3037 | 0.5 |
Brugia malayi | Matrixin family protein | 0.2168 | 0.2435 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.2168 | 0.2435 | 0.3075 |
Brugia malayi | Hemopexin family protein | 0.2754 | 0.3182 | 0.4305 |
Loa Loa (eye worm) | hypothetical protein | 0.2713 | 0.3129 | 0.4217 |
Schistosoma mansoni | hypothetical protein | 0.2754 | 0.3182 | 1 |
Brugia malayi | Matrixin family protein | 0.2168 | 0.2435 | 0.3075 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2713 | 0.3129 | 0.9831 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.2168 | 0.2435 | 0.3075 |
Loa Loa (eye worm) | matrixin family protein | 0.4809 | 0.5799 | 0.8619 |
Onchocerca volvulus | Matrilysin homolog | 0.5354 | 0.6492 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.2641 | 0.3037 | 0.4067 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.1506 | 0.1592 | 0.4925 |
Brugia malayi | Matrixin family protein | 0.2168 | 0.2435 | 0.3075 |
Brugia malayi | Matrixin family protein | 0.5467 | 0.6636 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.8108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2168 | 0.2435 | 0.3075 |
Onchocerca volvulus | 0.2754 | 0.3182 | 0.1839 | |
Brugia malayi | Matrixin family protein | 0.2168 | 0.2435 | 0.3075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Approximate colony formation unit (functional) | = 7700000 (g kidney)-1 | Antifungal activity against Candida albicans at an intraperitoneal dose of 20 mg/kg twice a day for 6 days in mice | ChEMBL. | 14980649 |
Zone size (functional) | = 24 mM | Antifungal activity against Candida albicans at a concentration of 1 mg/mL in MeOH; Zone: hazy | ChEMBL. | 14980649 |
Zone size (functional) | = 33 mM | Antifungal activity against Candida albicans at a concentration of 2 mg/mL in MeOH | ChEMBL. | 14980649 |
Zone size (functional) | = 38 mM | Antifungal activity against Candida albicans at a concentration of 5 mg/mL in MeOH | ChEMBL. | 14980649 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.