Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase type II | 0.0184 | 0.252 | 1 |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0184 | 0.252 | 1 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.037 | 0.1468 |
Brugia malayi | Hexokinase family protein | 0.0184 | 0.252 | 1 |
Schistosoma mansoni | hexokinase | 0.0184 | 0.252 | 0.5 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0387 | 1 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0387 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0184 | 0.252 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0184 | 0.252 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0184 | 0.252 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0184 | 0.252 | 0.5 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0387 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0184 | 0.252 | 0.5 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0387 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0387 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0387 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Brugia malayi | hexokinase | 0.0184 | 0.252 | 1 |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0387 | 1 | 1 |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0184 | 0.252 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative activity (functional) | = 27 % | Relative activity for inhibition of rat liver vitamin K dependent carboxylase mediated carboxylation of pentapeptide at 1 mM. | ChEMBL. | 7252980 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.