Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.1427 | 0.1427 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0196 | 0.1145 | 0.1145 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0082 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0426 | 0.346 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.1076 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0792 | 0.7141 | 0.8962 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0196 | 0.1145 | 0.1438 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0142 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0224 | 0.1427 | 0.1427 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0732 | 0.654 | 0.654 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0142 | 0.0601 | 0.0601 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0224 | 0.1427 | 0.1792 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0732 | 0.654 | 0.654 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0142 | 0.0601 | 0.5243 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0994 | 0.9173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.0601 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0601 | 0.0601 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0426 | 0.346 | 0.3772 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0196 | 0.1145 | 0.1249 |
Loa Loa (eye worm) | glutamate receptor | 0.0344 | 0.2633 | 0.2633 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1076 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0874 | 0.7968 | 1 |
Leishmania major | extracellular receptor, putative | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0732 | 0.654 | 0.713 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0142 | 0.0601 | 0.5243 |
Loa Loa (eye worm) | glutamate receptor | 0.0874 | 0.7968 | 0.7968 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0224 | 0.1427 | 0.1427 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0142 | 0.0601 | 0.0754 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0196 | 0.1145 | 0.1145 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0196 | 0.1145 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0196 | 0.1145 | 0.1145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43 uM | Binding affinity to Tsg101 (unknown origin) | ChEMBL. | 18083557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.