Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0673 | 0.6728 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0673 | 0.6728 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0689 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0673 | 0.6728 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0673 | 0.6728 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6728 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0673 | 0.6728 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0673 | 0.6728 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0673 | 0.6728 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0673 | 0.6728 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.6728 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0673 | 0.6728 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0673 | 0.6728 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0673 | 0.6728 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.064 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.55 ug injection-1 | Antiovulatory activity on proestrus was measured by administering as a solution in 50% propylene glycol / 0.9% saline in rat | ChEMBL. | 2447279 |
ED50 (functional) | = 9.5 ug injection-1 | Antiovulatory activity on diestrus II following administration as a solution in corn oil (24h earlier) in rat. | ChEMBL. | 2447279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.