Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | high affinity choline transporter 1 | 0.1786 | 0.2542 | 0.2542 |
Schistosoma mansoni | sodium/solute symporter | 0.1786 | 0.2542 | 0.2542 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.1786 | 0.2542 | 0.2542 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.1786 | 0.2542 | 0.2542 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.1786 | 0.2542 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.6998 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.6998 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.6998 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.6998 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.6998 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1786 | 0.2542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1786 | 0.2542 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.1786 | 0.2542 | 1 |
Schistosoma mansoni | inositol transporter | 0.6998 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.1786 | 0.2542 | 0.2542 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.6998 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.6998 | 1 | 1 |
Brugia malayi | GH02984p | 0.1786 | 0.2542 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.1786 | 0.2542 | 0.2542 |
Onchocerca volvulus | 0.1786 | 0.2542 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 270 nM | Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. | ChEMBL. | 9464361 |
EC50 (functional) | = 270 nM | Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. | ChEMBL. | 9464361 |
Efficacy (functional) | = 77 % | Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. | ChEMBL. | 9464361 |
Efficacy (functional) | = 77 % | Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. | ChEMBL. | 9464361 |
Ki (binding) | = 2.7 nM | The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. | ChEMBL. | 9464361 |
Ki (binding) | = 2.7 nM | The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. | ChEMBL. | 9464361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.