Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin-like protease protein 5 | 0.0443 | 0.0849 | 0.081 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0152 | 0.0048 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0443 | 0.0849 | 0.3218 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Toxoplasma gondii | PAN domain-containing protein | 0.1503 | 0.3758 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0443 | 0.0849 | 0.3218 |
Onchocerca volvulus | 0.1058 | 0.2536 | 0.2518 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1058 | 0.2536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0849 | 0.0855 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.115 | 0.2789 | 0.2809 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Mycobacterium ulcerans | hypothetical protein | 0.0443 | 0.0849 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1058 | 0.2536 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Onchocerca volvulus | 0.0443 | 0.0849 | 0.081 | |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0849 | 0.0855 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.3751 | 0.9931 | 0.9931 |
Echinococcus multilocularis | Mastin | 0.0443 | 0.0849 | 0.3218 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0443 | 0.0849 | 0.3218 |
Loa Loa (eye worm) | SRC-1 | 0.0152 | 0.0048 | 0.0049 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0443 | 0.0849 | 0.0805 |
Onchocerca volvulus | 0.0443 | 0.0849 | 0.081 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | trypsin family protein | 0.0443 | 0.0849 | 0.0855 |
Onchocerca volvulus | 0.3751 | 0.9931 | 1 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0443 | 0.0849 | 0.3218 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1058 | 0.2536 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1058 | 0.2536 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.115 | 0.2789 | 0.2774 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Brugia malayi | Trypsin family protein | 0.3751 | 0.9931 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0443 | 0.0849 | 0.3218 |
Loa Loa (eye worm) | hypothetical protein | 0.3751 | 0.9931 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.1503 | 0.3758 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Brugia malayi | Trypsin family protein | 0.0443 | 0.0849 | 0.081 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0443 | 0.0849 | 0.3218 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 0.2536 | 0.2554 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Echinococcus granulosus | enteropeptidase | 0.0443 | 0.0849 | 0.3218 |
Schistosoma mansoni | hypothetical protein | 0.1058 | 0.2536 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0048 | 0.0049 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0443 | 0.0849 | 0.3218 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK protein kinase | 0.0152 | 0.0048 | 0.0049 |
Brugia malayi | hypothetical protein | 0.0443 | 0.0849 | 0.081 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0152 | 0.0048 | 0.0049 |
Onchocerca volvulus | 0.0443 | 0.0849 | 0.081 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0456 | 0.0884 | 0.084 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0443 | 0.0849 | 0.3218 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0849 | 0.0855 |
Onchocerca volvulus | 0.0443 | 0.0849 | 0.081 | |
Brugia malayi | Trypsin family protein | 0.0443 | 0.0849 | 0.081 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0849 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.3751 | 0.9931 | 1 |
Onchocerca volvulus | 0.0443 | 0.0849 | 0.081 | |
Echinococcus granulosus | Mastin | 0.0443 | 0.0849 | 0.3218 |
Brugia malayi | Kringle domain containing protein | 0.1058 | 0.2536 | 0.2518 |
Schistosoma mansoni | hypothetical protein | 0.0443 | 0.0849 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0849 | 0.0855 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1058 | 0.2536 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Brugia malayi | Trypsin family protein | 0.0443 | 0.0849 | 0.081 |
Schistosoma mansoni | hypothetical protein | 0.0443 | 0.0849 | 0.0805 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0443 | 0.0849 | 0.3218 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0443 | 0.0849 | 0.0805 |
Leishmania major | hypothetical protein, conserved | 0.1058 | 0.2536 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0443 | 0.0849 | 0.081 |
Onchocerca volvulus | 0.3308 | 0.8713 | 0.8768 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0152 | 0.0048 | 0.0049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 5000 uM | Inhibition potency against Cholecystokinin-8-Inactivating Peptidase (Serine Peptidase). | ChEMBL. | 10691692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.