Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0716 | 1 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0716 | 1 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0716 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0716 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 1 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0716 | 1 | 0.5 |
Onchocerca volvulus | 0.0716 | 1 | 0.5 | |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0716 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0716 | 1 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0716 | 1 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0716 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0426 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.9012 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.