Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2032 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2032 | 1 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.1484 | 0.4814 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.2032 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.1484 | 0.4814 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.1484 | 0.4814 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.2032 | 1 | 1 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.1484 | 0.4814 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.2032 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Giardia lamblia | CDC72 | 0.1484 | 0.4814 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.1484 | 0.4814 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2032 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.