Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SET domain-containing protein | 0.0512 | 0.5 | 0.5 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0512 | 0.5 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0512 | 0.5 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0512 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Tested for antagonistic properties by using NC(1-13)-NH2; In active at 10 microM | ChEMBL. | 9191955 | |
Emax (functional) | % | Tested for maximal effect induced by agonist at 10 microM; Inactive | ChEMBL. | 9191955 |
Log EC50 (functional) | Tested for apparent affinity on electrically stimulated mouse vas deferens at 10 microM; Inactive | ChEMBL. | 9191955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.