Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase, putative | 0.0744 | 0.4126 | 0.4126 |
Plasmodium falciparum | histone deacetylase 1 | 0.1773 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.1199 | 0.6725 | 0.6725 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.1199 | 0.6725 | 0.6725 |
Giardia lamblia | Histone deacetylase | 0.1773 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0166 | 0.0828 | 0.0828 |
Leishmania major | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1199 | 0.6725 | 0.6725 |
Schistosoma mansoni | tyrosine kinase | 0.0598 | 0.3295 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.2599 | 0.2599 |
Echinococcus granulosus | histone deacetylase 6 | 0.1199 | 0.6725 | 0.6725 |
Echinococcus granulosus | histone deacetylase 7 | 0.1199 | 0.6725 | 0.6725 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.036 | 0.194 | 0.194 |
Schistosoma mansoni | tyrosine kinase | 0.0598 | 0.3295 | 0.3295 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.1773 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0744 | 0.4126 | 0.4126 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.1773 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.122 | 0.6841 | 0.6841 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Plasmodium falciparum | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1126 | 0.6306 | 0.6306 |
Plasmodium vivax | histone deacetylase, putative | 0.0744 | 0.4126 | 0.4126 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.194 | 0.194 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1199 | 0.6725 | 0.6725 |
Plasmodium vivax | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0744 | 0.4126 | 0.4126 |
Brugia malayi | Protein kinase domain containing protein | 0.036 | 0.194 | 0.194 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.1773 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.1773 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1773 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.4126 | 0.4126 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1773 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0598 | 0.3295 | 0.3295 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Loa Loa (eye worm) | hypothetical protein | 0.1773 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0605 | 0.3337 | 0.3337 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.1773 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.194 | 0.194 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0744 | 0.4126 | 0.4126 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.1773 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0744 | 0.4126 | 0.4126 |
Echinococcus granulosus | histone deacetylase 3 | 0.1773 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.1199 | 0.6725 | 0.6725 |
Echinococcus granulosus | insulin receptor | 0.036 | 0.194 | 0.194 |
Leishmania major | histone deacetylase, putative | 0.1773 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0605 | 0.3337 | 0.3337 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1773 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.036 | 0.194 | 0.194 |
Trypanosoma brucei | histone deacetylase 3 | 0.1199 | 0.6725 | 0.6725 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0605 | 0.3337 | 0.3337 |
Echinococcus granulosus | histone deacetylase 6 | 0.122 | 0.6841 | 0.6841 |
Onchocerca volvulus | 0.0145 | 0.0713 | 0.1727 | |
Leishmania major | histone deacetylase, putative | 0.1773 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0744 | 0.4126 | 0.4126 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1199 | 0.6725 | 0.6725 |
Echinococcus multilocularis | histone deacetylase 7 | 0.1199 | 0.6725 | 0.6725 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.2482 | 0.2482 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Echinococcus granulosus | histone deacetylase 1 | 0.1773 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0744 | 0.4126 | 0.4126 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0166 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | histone deacetylase | 0.1199 | 0.6725 | 0.6725 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1773 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.1773 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.1773 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.1773 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.1199 | 0.6725 | 0.6725 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1126 | 0.6306 | 0.6306 |
Trypanosoma brucei | histone deacetylase 4 | 0.1199 | 0.6725 | 0.6725 |
Schistosoma mansoni | tyrosine kinase | 0.1126 | 0.6306 | 0.6306 |
Echinococcus multilocularis | insulin receptor | 0.036 | 0.194 | 0.194 |
Echinococcus granulosus | histone deacetylase | 0.1199 | 0.6725 | 0.6725 |
Echinococcus multilocularis | histone deacetylase 6 | 0.122 | 0.6841 | 0.6841 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1773 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1773 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1199 | 0.6725 | 0.6725 |
Trypanosoma brucei | histone deacetylase 2 | 0.0744 | 0.4126 | 0.4126 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0744 | 0.4126 | 0.4126 |
Entamoeba histolytica | histone deacetylase, putative | 0.1773 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.1199 | 0.6725 | 0.6725 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0744 | 0.4126 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0155 | 0.0769 | 0.1862 |
Brugia malayi | Histone deacetylase family protein | 0.1199 | 0.6725 | 0.6725 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0744 | 0.4126 | 0.4126 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1126 | 0.6306 | 0.6306 |
Schistosoma mansoni | tyrosine kinase | 0.0605 | 0.3337 | 0.3337 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1126 | 0.6306 | 0.6306 |
Echinococcus multilocularis | 0.0348 | 0.187 | 0.187 | |
Brugia malayi | Histone deacetylase family protein | 0.1199 | 0.6725 | 0.6725 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1773 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1773 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.1773 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.1199 | 0.6725 | 0.6725 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0744 | 0.4126 | 0.4126 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.036 | 0.194 | 0.194 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0605 | 0.3337 | 0.3337 |
Echinococcus multilocularis | histone deacetylase | 0.1199 | 0.6725 | 0.6725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.