Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Echinococcus granulosus | c src tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.062 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0392 | 0.4032 | 0.4032 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.062 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.062 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.062 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.062 | 1 | 1 |
Entamoeba histolytica | SH2 domain containing protein | 0.0392 | 0.4032 | 0.4032 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.062 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0392 | 0.4032 | 0.4032 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.062 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.062 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.062 | 1 | 1 |
Brugia malayi | SRC-1 | 0.062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 726 nM | Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 726 nM | Binding affinity towards human Dopamine Receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 1000 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | > 1000 nM | Binding affinity towards Alpha-1 adrenergic receptor via standard competitive displacement assay using rat brain homogenate with [3H]-prazosin as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 5847 nM | Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Ki (binding) | = 5847 nM | Binding affinity towards human Dopamine receptor D2 was determined via standard competitive displacement assay using [3H]-YM 09151 as radioligand | ChEMBL. | 12372512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.