Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.1753 | 0.8782 | 1 |
Giardia lamblia | Thioredoxin reductase | 0.1958 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Brugia malayi | Casein kinase II, alpha chain | 0.1753 | 0.8782 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Leishmania major | casein kinase II, putative | 0.1753 | 0.8782 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Schistosoma mansoni | protein kinase | 0.1753 | 0.8782 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.1958 | 1 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.1958 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0955 | 0.4027 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.1753 | 0.8782 | 0.8782 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.1958 | 1 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Giardia lamblia | Kinase, CMGC CK2 | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Trypanosoma brucei | Casein kinase II | 0.1753 | 0.8782 | 1 |
Plasmodium vivax | unspecified product | 0.1753 | 0.8782 | 1 |
Giardia lamblia | Casein kinase II beta chain | 0.0955 | 0.4027 | 0.4027 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.1753 | 0.8782 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.1958 | 1 | 1 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.1958 | 1 | 1 |
Loa Loa (eye worm) | Csnk2b protein | 0.0955 | 0.4027 | 0.4586 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.1753 | 0.8782 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.1958 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trypanosoma cruzi | casein kinase II, putative | 0.1753 | 0.8782 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1753 | 0.8782 | 0.8782 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.1958 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.1753 | 0.8782 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.1753 | 0.8782 | 1 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.1958 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.1753 | 0.8782 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.1958 | 1 | 1 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.1958 | 1 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0955 | 0.4027 | 0.4027 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0955 | 0.4027 | 0.5 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0955 | 0.4027 | 0.4027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1753 | 0.8782 | 0.8782 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0955 | 0.4027 | 0.4027 |
Brugia malayi | Csnk2b protein | 0.0955 | 0.4027 | 0.4586 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.1958 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 8.56 uM | Growth inhibition against human HeLa cells after 72 hrs by inverted microscopy | ChEMBL. | 23353738 |
IC50 (functional) | > 142.7 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 23353738 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.