Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA topoisomerase II, putative | 0.0976 | 0.2148 | 0.1897 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2259 | 0.5575 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0359 | 0.0501 | 0.0197 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0976 | 0.2148 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0689 | 0.1382 | 0.2036 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0359 | 0.0501 | 0.0197 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3917 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0689 | 0.1382 | 0.2036 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0359 | 0.0501 | 0.0197 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0689 | 0.1382 | 0.2036 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0976 | 0.2148 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3917 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0689 | 0.1382 | 0.2036 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0359 | 0.0501 | 0.0197 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0976 | 0.2148 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0976 | 0.2148 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0359 | 0.0501 | 0.0197 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0976 | 0.2148 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3917 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0689 | 0.1382 | 0.2036 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0745 | 0.1531 | 0.6644 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3917 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2259 | 0.5575 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3917 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3917 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0976 | 0.2148 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.085 | 0.1812 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0651 | 0.1282 | 0.529 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2259 | 0.5575 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0976 | 0.2148 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1284 | 0.297 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0976 | 0.2148 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0976 | 0.2148 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0745 | 0.1531 | 0.6644 |
Schistosoma mansoni | DNA topoisomerase II | 0.0976 | 0.2148 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2633 | 0.6573 | 0.6464 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0976 | 0.2148 | 0.3559 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0745 | 0.1531 | 0.6644 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0359 | 0.0501 | 0.037 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0745 | 0.1531 | 0.6644 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2222 | 0.5476 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0745 | 0.1531 | 0.6644 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0287 | 0.031 | 0.1043 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0976 | 0.2148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0651 | 0.1282 | 0.529 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0976 | 0.2148 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0359 | 0.0501 | 0.0197 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2259 | 0.5575 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0976 | 0.2148 | 0.1897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.