Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1006 | 0.5263 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3425 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0345 | 0.0293 | 0.0293 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0858 | 0.1912 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1975 | 0.5431 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0858 | 0.1912 | 0.3595 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0607 | 0.1119 | 0.206 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0345 | 0.0293 | 0.0551 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3425 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0858 | 0.1912 | 0.1912 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0858 | 0.1912 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0345 | 0.0293 | 0.0293 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0858 | 0.1912 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0345 | 0.0293 | 0.0293 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3425 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0858 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.1006 | 0.5263 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3425 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3425 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1975 | 0.5431 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3425 | 1 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1117 | 0.2726 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0858 | 0.1912 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1975 | 0.5431 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0748 | 0.1564 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0345 | 0.0293 | 0.0293 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0858 | 0.1912 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0858 | 0.1912 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2308 | 0.6481 | 0.6481 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0607 | 0.1119 | 0.206 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0858 | 0.1912 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0858 | 0.1912 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0858 | 0.1912 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1939 | 0.5319 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0607 | 0.1119 | 0.206 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0607 | 0.1119 | 0.206 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0345 | 0.0293 | 0.0293 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0858 | 0.1912 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0607 | 0.1119 | 0.206 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1975 | 0.5431 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0858 | 0.1912 | 0.1912 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0345 | 0.0293 | 0.0293 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0858 | 0.1912 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.