Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0172 | 0.85 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0138 | 0.5902 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0063 | 0 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0172 | 0.85 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0191 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0191 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0172 | 0.85 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0138 | 0.5902 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0191 | 1 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0191 | 1 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0191 | 1 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1684 | 0.0621 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5096 | 0.4469 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5096 | 0.4469 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0063 | 0 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0182 | 0.9342 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1644 | 0.0576 |
Schistosoma mansoni | DNA topoisomerase II | 0.0191 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0104 | 0.3184 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0172 | 0.85 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0138 | 0.5902 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0191 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0172 | 0.85 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0191 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1684 | 0.0621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.