Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0069 | 0.4233 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0116 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0094 | 0.7283 | 0.8549 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0069 | 0.4233 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0116 | 0.9984 | 0.9984 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.9984 | 1 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0116 | 0.9984 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0069 | 0.4233 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0116 | 1 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0116 | 0.9984 | 0.9984 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0116 | 1 | 0.5 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0116 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0034 | 0 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0116 | 1 | 0.5 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5819 | 0.683 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0034 | 0 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0069 | 0.4233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.852 | 1 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0069 | 0.4233 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0116 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.