Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0149 | 0.154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0751 | 0.4876 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.037 | 0.5341 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0149 | 0.154 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0149 | 0.154 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.037 | 0.5341 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0129 | 0.1194 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0639 | 1 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0149 | 0.154 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0149 | 0.154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0751 | 0.4876 |
Schistosoma mansoni | DNA topoisomerase II | 0.0149 | 0.154 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0149 | 0.154 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0639 | 1 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0639 | 1 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.022 | 0.2761 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0639 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0639 | 1 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0639 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0149 | 0.154 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.037 | 0.5341 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0149 | 0.154 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0149 | 0.154 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0149 | 0.154 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.037 | 0.5341 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0149 | 0.154 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.037 | 0.5341 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.