Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0357 | 0.2728 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0407 | 0.3678 | 0.2827 |
Echinococcus granulosus | prolyl endopeptidase | 0.0454 | 0.4577 | 0.3847 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0454 | 0.4577 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0407 | 0.3678 | 0.2827 |
Toxoplasma gondii | prolyl endopeptidase | 0.0454 | 0.4577 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0739 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0454 | 0.4577 | 0.3847 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0454 | 0.4577 | 0.3847 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0276 | 0.1187 | 0.2592 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0739 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0276 | 0.1187 | 0.2592 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0276 | 0.1187 | 0.2592 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0739 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0214 | 0 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0454 | 0.4577 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0739 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0276 | 0.1187 | 0.2592 |
Trypanosoma brucei | prolyl endopeptidase | 0.0454 | 0.4577 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0454 | 0.4577 | 0.3847 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0276 | 0.1187 | 0.2592 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0214 | 0 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0454 | 0.4577 | 0.3847 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0407 | 0.3678 | 0.2827 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0739 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 47.3124 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.