Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PAN domain-containing protein | 0.1853 | 0.7089 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0312 | 0.0898 |
Onchocerca volvulus | 0.083 | 0.2815 | 0.8117 | |
Echinococcus granulosus | laminin | 0.0231 | 0.0312 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0312 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0312 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0987 | 0.3468 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0231 | 0.0312 | 0.0898 |
Onchocerca volvulus | Arrow homolog | 0.0231 | 0.0312 | 0.0898 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1213 | 0.4414 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.1853 | 0.7089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0312 | 0.0898 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.255 | 1 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1213 | 0.4414 | 1 |
Brugia malayi | Trypsin family protein | 0.0987 | 0.3468 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0987 | 0.3468 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.255 | 1 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0231 | 0.0312 | 0.0898 |
Schistosoma mansoni | egf-like domain protein | 0.0231 | 0.0312 | 0.0898 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0231 | 0.0312 | 0.0898 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0231 | 0.0312 | 0.0898 |
Onchocerca volvulus | 0.0987 | 0.3468 | 1 | |
Echinococcus granulosus | Tolloid protein 1 | 0.0231 | 0.0312 | 0.0706 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0231 | 0.0312 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0312 | 0.0898 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0987 | 0.3468 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0231 | 0.0312 | 0.0898 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0231 | 0.0312 | 0.0706 |
Echinococcus multilocularis | laminin | 0.0231 | 0.0312 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0987 | 0.3468 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0231 | 0.0312 | 0.0706 |
Brugia malayi | Fibulin-1 precursor | 0.0231 | 0.0312 | 0.0898 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.