TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.437 | Formula: C22H23N3O2
H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1(C)CCN1CCOc1ccccc1)Nc1cnc2c(c1)cccc2
InChi: 1S/C22H23N3O2/c1-22(11-12-25(22)13-14-27-19-8-3-2-4-9-19)21(26)24-18-15-17-7-5-6-10-20(17)23-16-18/h2-10,15-16H,11-14H2,1H3,(H,24,26)
InChiKey: UOTWFJDZWBUBLO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0189	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0463	0.8852	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Echinococcus multilocularis	N chimaerin	0.0275	0.2773	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0189	0	0.5
Onchocerca volvulus		0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0463	0.8852	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0463	0.8852	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0463	0.8852	1
Leishmania major	protein kinase, putative	0.0189	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.0463	0.8852	0.8852
Loa Loa (eye worm)	hypothetical protein	0.0499	1	1
Onchocerca volvulus		0.0463	0.8852	0.8852
Leishmania major	hypothetical protein, conserved	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Giardia lamblia	Kinase, NEK	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Onchocerca volvulus		0.0275	0.2773	0.2773
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0463	0.8852	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0275	0.2773	0.2773
Schistosoma mansoni	vav2	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Giardia lamblia	Protein 21.1	0.0189	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Giardia lamblia	Kinase, NEK	0.0189	0	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0275	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Schistosoma mansoni	nck2/grb4	0.0275	0.2773	0.2773
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0189	0	0.5
Schistosoma mansoni	tensin-related	0.0275	0.2773	0.2773
Echinococcus multilocularis	tyrosine kinase	0.0463	0.8852	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0189	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0275	0.2773	0.3133
Echinococcus multilocularis		0.0275	0.2773	0.3133
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0275	0.2773	0.3133
Trichomonas vaginalis	CAMK family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	STAT protein	0.0275	0.2773	0.2773
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/ROR protein kinase	0.0277	0.2857	0.2857
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Schistosoma mansoni	SH2A	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0499	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Toxoplasma gondii	protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.8852	1
Brugia malayi	Variant SH3 domain containing protein	0.0275	0.2773	0.2773
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0463	0.8852	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.8852	1
Toxoplasma gondii	STE kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0275	0.2773	0.3133
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0275	0.2773	0.3133
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0275	0.2773	0.3133
Echinococcus granulosus	SH2 motif	0.0275	0.2773	0.3133
Echinococcus multilocularis	tensin	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tensin	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Onchocerca volvulus		0.0275	0.2773	0.2773
Trichomonas vaginalis	STE family protein kinase	0.0189	0	0.5
Echinococcus granulosus	N chimaerin	0.0275	0.2773	0.3133
Schistosoma mansoni	tensin	0.0275	0.2773	0.2773
Loa Loa (eye worm)	SH2 domain-containing protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0463	0.8852	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Brugia malayi	Sex muscle abnormal protein 5	0.0275	0.2773	0.2773
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0275	0.2773	0.3133
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/ABL protein kinase	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0275	0.2773	0.3133
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0189	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0275	0.2773	0.3133
Trypanosoma brucei	protein kinase, putative	0.0189	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0275	0.2773	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0189	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0275	0.2773	0.2773
Schistosoma mansoni	GTPase activating protein	0.0275	0.2773	0.2773
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0463	0.8852	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0275	0.2773	0.3133
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0463	0.8852	0.8852
Onchocerca volvulus		0.0463	0.8852	0.8852
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0463	0.8852	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	SH2 motif	0.0275	0.2773	0.3133
Plasmodium falciparum	tyrosine kinase-like protein	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	SRC-1	0.0463	0.8852	0.8852
Echinococcus multilocularis	SH2 motif	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0463	0.8852	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.2773	0.3133
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0275	0.2773	0.2773
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0463	0.8852	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0275	0.2773	0.2773
Trypanosoma brucei	Pseudokinase, putative	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Schistosoma mansoni	hypothetical protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0443	0.8207	0.8207
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0189	0	0.5
Giardia lamblia	Kinase	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0463	0.8852	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0275	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Echinococcus granulosus	SH2 motif	0.0275	0.2773	0.3133
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0463	0.8852	0.8852
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0189	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0277	0.2857	0.2857
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0463	0.8852	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0275	0.2773	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Echinococcus granulosus	tyrosine protein kinase shark	0.0463	0.8852	1
Plasmodium falciparum	protein kinase, putative	0.0189	0	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0499	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0189	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0463	0.8852	1
Brugia malayi	hypothetical protein	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0463	0.8852	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Echinococcus granulosus	signal transduction protein lnk realted	0.0275	0.2773	0.3133
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0275	0.2773	0.2773
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0275	0.2773	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0463	0.8852	0.8852
Plasmodium vivax	protein kinase, putative	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0463	0.8852	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0189	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0463	0.8852	1
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0275	0.2773	0.2773
Leishmania major	protein kinase, putative	0.0189	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.0275	0.2773	0.3133
Echinococcus granulosus	expressed conserved protein	0.0275	0.2773	0.3133
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0275	0.2773	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0499	1	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Brugia malayi	Variant SH3 domain containing protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0275	0.2773	0.2773
Onchocerca volvulus		0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0275	0.2773	0.3133
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0463	0.8852	1
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Brugia malayi	Protein kinase domain containing protein	0.0463	0.8852	0.8852
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	SRC-1	0.0463	0.8852	0.8852
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Brugia malayi	SH2 domain containing protein	0.0463	0.8852	0.8852
Echinococcus granulosus	tensin	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0463	0.8852	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0275	0.2773	0.3133
Echinococcus granulosus	SHC transforming protein 3	0.0275	0.2773	0.3133
Echinococcus granulosus	NCK adaptor protein	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0463	0.8852	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0463	0.8852	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.8852	0.8852
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Plasmodium falciparum	protein kinase, putative	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0275	0.2773	0.3133
Brugia malayi	SH2 domain containing protein	0.0463	0.8852	0.8852
Onchocerca volvulus		0.0275	0.2773	0.2773
Schistosoma mansoni	suppressor of cytokine signaling	0.0275	0.2773	0.2773
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0275	0.2773	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0499	1	1
Schistosoma mansoni	tensin	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0275	0.2773	0.3133
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Onchocerca volvulus		0.0463	0.8852	0.8852
Echinococcus granulosus	c src tyrosine kinase	0.0463	0.8852	1
Brugia malayi	Tensin	0.0275	0.2773	0.2773
Schistosoma mansoni	tensin-related	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0463	0.8852	0.8852
Schistosoma mansoni	adapter molecule crk	0.0275	0.2773	0.2773
Brugia malayi	SH2 domain containing protein	0.0275	0.2773	0.2773
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0463	0.8852	1
Echinococcus multilocularis	SH2 motif	0.0275	0.2773	0.3133
Schistosoma mansoni	signal transduction protein lnk-related	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Schistosoma mansoni	tensin	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0275	0.2773	0.3133
Entamoeba histolytica	SH2 domain containing protein	0.0275	0.2773	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0463	0.8852	1
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Brugia malayi	hypothetical protein	0.0463	0.8852	0.8852
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0463	0.8852	0.8852
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Echinococcus multilocularis	c src tyrosine kinase	0.0463	0.8852	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0275	0.2773	0.3133
Brugia malayi	protein-tyrosine kinase	0.0463	0.8852	0.8852
Echinococcus multilocularis	SH2 domain containing protein 7	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Schistosoma mansoni	hypothetical protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0463	0.8852	0.8852
Echinococcus granulosus	hypothetical protein	0.0275	0.2773	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.8852	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.8852	0.8852
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0275	0.2773	0.2773
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0275	0.2773	0.2773
Schistosoma mansoni	shc transforming protein	0.0275	0.2773	0.2773
Trypanosoma cruzi	protein kinase, putative	0.0189	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0189	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Onchocerca volvulus		0.0275	0.2773	0.2773
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0275	0.2773	0.2773
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0275	0.2773	0.2773
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.2773	0.2773
Schistosoma mansoni	tyrosine kinase	0.0463	0.8852	0.8852
Brugia malayi	Variant SH3 domain containing protein	0.0275	0.2773	0.2773
Brugia malayi	RhoGAP domain containing protein	0.0275	0.2773	0.2773
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0275	0.2773	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0463	0.8852	1
Trichomonas vaginalis	TKL family protein kinase	0.0189	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2360271

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1752386