Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.1253 | 0.2151 | 0.2151 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.2076 | 0.5682 | 0.5682 |
Schistosoma mansoni | glutamate receptor kainate | 0.1696 | 0.405 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.351 | 0.2018 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0949 | 0.0846 | 0.0846 |
Echinococcus multilocularis | NMDA receptor | 0.0949 | 0.0846 | 0.0846 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0949 | 0.0846 | 0.0846 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Brugia malayi | Glutamate receptor 2 precursor | 0.2823 | 0.8886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.351 | 0.2018 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1513 | 0.3264 | 0.5862 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Echinococcus granulosus | glutamate receptor 2 | 0.2576 | 0.7828 | 0.7828 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1956 | 0.5164 | 0.5164 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1195 | 0.19 | 0.19 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.3083 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.2576 | 0.7828 | 0.7828 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.2823 | 0.8886 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.2823 | 0.8886 | 0.8886 |
Echinococcus multilocularis | glutamate receptor 2 | 0.3083 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0949 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.157 | 0.351 | 0.2018 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.3083 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.1253 | 0.2151 | 0.2151 |
Echinococcus granulosus | glutamate receptor 1 | 0.157 | 0.351 | 0.351 |
Echinococcus granulosus | glutamate receptor 4 | 0.157 | 0.351 | 0.351 |
Brugia malayi | Glutamate receptor 1 precursor | 0.2823 | 0.8886 | 0.5 |
Echinococcus multilocularis | glutamate receptor 4 | 0.157 | 0.351 | 0.351 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.2076 | 0.5682 | 0.5682 |
Schistosoma mansoni | glutamate receptor kainate | 0.1696 | 0.405 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.509 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.26 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.185 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.