Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA topoisomerase 2 | 0.0942 | 0.2139 | 0.1904 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0942 | 0.2139 | 0.1904 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2537 | 0.6574 | 0.6472 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0942 | 0.2139 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0942 | 0.2139 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0665 | 0.137 | 0.2048 |
Brugia malayi | DNA topoisomerase III | 0.0277 | 0.029 | 0.124 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0665 | 0.137 | 0.2048 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2137 | 0.546 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0665 | 0.137 | 0.2048 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0277 | 0.029 | 0.0983 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0665 | 0.137 | 0.2048 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0362 | 0.0526 | 0.0457 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0942 | 0.2139 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0942 | 0.2139 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0362 | 0.0526 | 0.0243 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2174 | 0.5565 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0942 | 0.2139 | 0.3576 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0942 | 0.2139 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0362 | 0.0526 | 0.0243 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0277 | 0.029 | 0.124 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2174 | 0.5565 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0942 | 0.2139 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0277 | 0.029 | 0.124 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3769 | 1 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0277 | 0.029 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0628 | 0.1266 | 0.5862 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0942 | 0.2139 | 1 |
Onchocerca volvulus | 0.0277 | 0.029 | 0.124 | |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0942 | 0.2139 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0942 | 0.2139 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0362 | 0.0526 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0628 | 0.1266 | 0.5862 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0942 | 0.2139 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0362 | 0.0526 | 0.0243 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3769 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3769 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0362 | 0.0526 | 0.0243 |
Leishmania major | DNA topoisomerase ii | 0.0665 | 0.137 | 0.2048 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3769 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3769 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3769 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2174 | 0.5565 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.082 | 0.1801 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0362 | 0.0526 | 0.0243 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0942 | 0.2139 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0942 | 0.2139 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2174 | 0.5565 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0277 | 0.029 | 0.124 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1232 | 0.2947 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.