Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0223 | 0.1685 | 0.1579 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.185 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0126 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0178 | 0.0504 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.185 | 1 |
Onchocerca volvulus | 0.0276 | 0.2128 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0276 | 0.2128 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0089 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0089 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0178 | 0.0963 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0336 | 0.1816 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0126 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0178 | 0.0053 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0126 | 1 |
Mycobacterium tuberculosis | Possible exported protein | 0.1041 | 0.8468 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0126 | 0.0207 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1423 | 0.1313 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0336 | 0.1816 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0089 | 0.5 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1423 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0336 | 0.1401 |
Brugia malayi | hypothetical protein | 0.003 | 0.0089 | 0.0483 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0126 | 0.068 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0336 | 0.1401 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1423 | 0.1313 |
Echinococcus granulosus | geminin | 0.0191 | 0.1423 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.