Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trypanosoma cruzi | casein kinase II, putative | 0.3316 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Leishmania major | casein kinase II, putative | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Giardia lamblia | Casein kinase II beta chain | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.3316 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.3316 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.3316 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.3316 | 1 | 1 |
Loa Loa (eye worm) | casein kinase II | 0.0528 | 0.0784 | 0.0784 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.3316 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Loa Loa (eye worm) | Csnk2b protein | 0.1806 | 0.501 | 0.501 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1806 | 0.501 | 1 |
Schistosoma mansoni | protein kinase | 0.3316 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Brugia malayi | casein kinase II, putaitve | 0.0528 | 0.0784 | 0.0784 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Brugia malayi | Csnk2b protein | 0.1806 | 0.501 | 0.501 |
Entamoeba histolytica | protein kinase domain containing protein | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trypanosoma brucei | Casein kinase II | 0.3316 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1806 | 0.501 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3316 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.3316 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1806 | 0.501 | 0.4586 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.3316 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1806 | 0.501 | 0.4586 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 17.78 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.