Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2818 | 0.9634 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2582 | 0.8685 | 0.9015 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.1561 | 0.4586 | 0.4586 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.1561 | 0.4586 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.1561 | 0.4586 | 0.4586 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.2909 | 1 | 1 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.1561 | 0.4586 | 0.4586 |
Onchocerca volvulus | Deterin homolog | 0.1561 | 0.4586 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.1561 | 0.4586 | 0.4586 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.1561 | 0.4586 | 0.4586 |
Schistosoma mansoni | hypothetical protein | 0.1561 | 0.4586 | 1 |
Onchocerca volvulus | 0.1561 | 0.4586 | 1 | |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.2909 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.1561 | 0.4586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1561 | 0.4586 | 0.4761 |
Loa Loa (eye worm) | hypothetical protein | 0.1561 | 0.4586 | 0.4761 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.1561 | 0.4586 | 0.4586 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 80 uM | Inhibition of good protein synthesis in cell-free protein synthesis assay (TC/TL) in an Escherichia coli murine septicemia model | ChEMBL. | 15149653 |
IC50 (functional) | > 80 uM | Inhibition of good protein synthesis in cell-free protein synthesis assay (TC/TL) in an Escherichia coli murine septicemia model | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli ATCC 25922 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli MG1655 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli MG1655 tolC | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Klebsiella pneumoniae ATCC13882 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Enterobacter cloacae ATCC35030 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa PA01 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Staphylococcus aureus ATCC25293 | ChEMBL. | 15149653 |
MIC (functional) | = 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Streptococcus pneumoniae 1005 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli ATCC 25922 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli MG1655 | ChEMBL. | 15149653 |
MIC (functional) | > 256 ug ml-1 | Minimum inhibitory concentration (MIC) against Escherichia coli MG1655 tolC | ChEMBL. | 15149653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.