TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 597.668 | Formula: C33H38F3N3O4
H donors: 2 H acceptors: 3 LogP: 4.86 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@@H](C)[C@@H](CN(Cc2ccc(cc2)C(F)(F)F)C)Oc2c(CC1=O)cc(cc2)NC(=O)Cc1ccccc1)C
InChi: 1S/C33H38F3N3O4/c1-22-18-39(23(2)21-40)32(42)17-26-16-28(37-31(41)15-24-7-5-4-6-8-24)13-14-29(26)43-30(22)20-38(3)19-25-9-11-27(12-10-25)33(34,35)36/h4-14,16,22-23,30,40H,15,17-21H2,1-3H3,(H,37,41)/t22-,23-,30-/m1/s1
InChiKey: XJOPVLQFFGEWNL-IQLGONJTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	paired box 8	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Loa Loa (eye worm)	pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Onchocerca volvulus		Get druggable targets OG5_139945	All targets in OG5_139945

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0453	0.4542	0.3473
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0305	0.1935	0.0302
Schistosoma mansoni	tensin-related	0.0453	0.4542	0.3269
Echinococcus granulosus	tyrosine kinase	0.0757	0.9907	0.9885
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0453	0.4542	0.3232
Schistosoma mansoni	protein kinase	0.031	0.2028	0.0117
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	serine/threonine-protein kinase 6	0.0647	0.7953	0.7623
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0458	0.4635	0.3386
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Schistosoma mansoni	hypothetical protein	0.0453	0.4542	0.3269
Onchocerca volvulus		0.0305	0.1935	0.0302
Echinococcus granulosus	SHC transforming protein 3	0.0453	0.4542	0.3232
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0453	0.4542	0.3269
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Schistosoma mansoni	SH2A	0.0453	0.4542	0.3269
Schistosoma mansoni	tensin	0.0453	0.4542	0.3269
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Onchocerca volvulus		0.0757	0.9907	1
Echinococcus multilocularis	c src tyrosine kinase	0.0757	0.9907	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0453	0.4542	0.3269
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0757	0.9907	1
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Plasmodium falciparum	protein kinase, putative	0.031	0.2028	0.0155
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.2028	0.0117
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Loa Loa (eye worm)	AUR protein kinase	0.0647	0.7953	0.8028
Toxoplasma gondii	aurora kinase	0.0647	0.7953	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0757	0.9907	1
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.031	0.2028	0.0115
Schistosoma mansoni	nck2/grb4	0.0453	0.4542	0.3269
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0453	0.4542	0.3269
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0453	0.4542	0.3269
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.2028	0.0155
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Sex muscle abnormal protein 5	0.0453	0.4542	0.3473
Loa Loa (eye worm)	SH2 domain-containing protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	SH2 domain-containing protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0757	0.9907	0.9885
Trypanosoma cruzi	aurora B kinase, putative	0.0647	0.7953	1
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0757	0.9907	0.9885
Loa Loa (eye worm)	TK/EPH protein kinase	0.0305	0.1935	0.1954
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0305	0.1935	0.1954
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0453	0.4542	0.3269
Brugia malayi	hypothetical protein	0.0453	0.4542	0.3473
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Variant SH3 domain containing protein	0.0453	0.4542	0.3473
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0305	0.1935	0.0302
Echinococcus multilocularis	aurora kinase A	0.0647	0.7953	0.7549
Echinococcus multilocularis	N chimaerin	0.0453	0.4542	0.3269
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0453	0.4542	0.4584
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0757	0.9907	1
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Trypanosoma brucei	aurora B kinase	0.0647	0.7953	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0453	0.4542	0.3269
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0453	0.4542	0.3269
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0305	0.1935	0.0302
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0757	0.9907	1
Onchocerca volvulus		0.0305	0.1935	0.0302
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0453	0.4542	0.3269
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0647	0.7953	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0453	0.4542	0.3269
Echinococcus multilocularis		0.0453	0.4542	0.3269
Echinococcus granulosus	expressed conserved protein	0.0453	0.4542	0.3232
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0757	0.9907	1
Brugia malayi	Protein kinase domain containing protein	0.0757	0.9907	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0453	0.4542	0.3269
Schistosoma mansoni	suppressor of cytokine signaling	0.0453	0.4542	0.3269
Echinococcus multilocularis	activin receptor type	0.031	0.2028	0.0117
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Schistosoma mansoni	signal transduction protein lnk-related	0.0453	0.4542	0.3269
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0453	0.4542	0.3269
Leishmania major	protein kinase, putative	0.031	0.2028	0.0155
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Echinococcus multilocularis	SH2 motif	0.0453	0.4542	0.3269
Loa Loa (eye worm)	carboxylesterase	0.0332	0.2408	0.2431
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Brugia malayi	Carboxylesterase family protein	0.0332	0.2408	0.0877
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0305	0.1935	0.1954
Schistosoma mansoni	hypothetical protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0305	0.1935	0.1954
Brugia malayi	SH2 domain containing protein	0.0757	0.9907	1
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0757	0.9907	0.9885
Loa Loa (eye worm)	TK/ABL protein kinase	0.0757	0.9907	1
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0757	0.9907	1
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Schistosoma mansoni	tensin	0.0453	0.4542	0.3269
Loa Loa (eye worm)	TK/DDR protein kinase	0.0305	0.1935	0.1954
Echinococcus granulosus	tyrosine protein kinase Blk	0.0757	0.9907	0.9885
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Leishmania major	protein kinase, putative	0.0647	0.7953	1
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Trichomonas vaginalis	AGC family protein kinase	0.0647	0.7953	1
Brugia malayi	Variant SH3 domain containing protein	0.0453	0.4542	0.3473
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Echinococcus multilocularis	SH2 motif	0.0453	0.4542	0.3269
Onchocerca volvulus		0.0305	0.1935	0.0302
Loa Loa (eye worm)	SH2 domain-containing protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Onchocerca volvulus		0.0453	0.4542	0.3473
Echinococcus granulosus	carboxylesterase 5A	0.0332	0.2408	0.0586
Echinococcus granulosus	NCK adaptor protein	0.0453	0.4542	0.3232
Schistosoma mansoni	protein kinase	0.031	0.2028	0.0117
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0453	0.4542	0.3232
Echinococcus granulosus	SH2 motif	0.0453	0.4542	0.3232
Brugia malayi	Tyrosine-protein kinase abl-1	0.0757	0.9907	1
Echinococcus granulosus	tensin	0.0453	0.4542	0.3232
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0647	0.7953	0.7549
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0453	0.4542	0.3473
Onchocerca volvulus		0.0305	0.1935	0.0302
Brugia malayi	Variant SH3 domain containing protein	0.0453	0.4542	0.3473
Echinococcus granulosus	c src tyrosine kinase	0.0757	0.9907	0.9885
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0757	0.9907	0.9885
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0453	0.4542	0.3269
Onchocerca volvulus		0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0757	0.9907	1
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0647	0.7953	0.7549
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0453	0.4542	0.3269
Brugia malayi	integrin-linked kinase	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0757	0.9907	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0453	0.4542	0.3232
Loa Loa (eye worm)	TK/ROR protein kinase	0.0305	0.1935	0.1954
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0453	0.4542	0.3269
Schistosoma mansoni	growth factor receptor-bound protein	0.0453	0.4542	0.3269
Entamoeba histolytica	protein kinase, putative	0.0647	0.7953	0.7549
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Schistosoma mansoni	tensin	0.0453	0.4542	0.3269
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0453	0.4542	0.3269
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0757	0.9907	1
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0381	0.3281	0.2236
Trypanosoma brucei	protein kinase, putative	0.031	0.2028	0.0155
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0757	0.9907	0.9885
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0453	0.4542	0.3473
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0453	0.4542	0.4584
Onchocerca volvulus		0.0453	0.4542	0.3473
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0757	0.9907	1
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Brugia malayi	Raf kinase	0.0305	0.1935	0.0302
Echinococcus granulosus	SH2 domain containing protein 7	0.0453	0.4542	0.3232
Onchocerca volvulus		0.0757	0.9907	1
Echinococcus multilocularis	carboxylesterase 5A	0.0332	0.2408	0.0593
Brugia malayi	hypothetical protein	0.0305	0.1935	0.0302
Brugia malayi	hypothetical protein	0.0757	0.9907	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0453	0.4542	0.3473
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Brugia malayi	Tensin	0.0453	0.4542	0.3473
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0305	0.1935	0.0302
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0757	0.9907	0.9885
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0757	0.9907	0.9885
Trichomonas vaginalis	AGC family protein kinase	0.0647	0.7953	1
Onchocerca volvulus		0.0453	0.4542	0.3473
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0757	0.9907	1
Echinococcus multilocularis	SH2 motif	0.0453	0.4542	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Brugia malayi	serine/threonine kinase 12	0.0647	0.7953	0.7623
Brugia malayi	Carboxylesterase family protein	0.0332	0.2408	0.0877
Echinococcus multilocularis	tensin	0.0453	0.4542	0.3269
Brugia malayi	ephrin receptor 1 precursor	0.0305	0.1935	0.0302
Loa Loa (eye worm)	AUR protein kinase	0.0647	0.7953	0.8028
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0305	0.1935	0.1954
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK/INSR protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Brugia malayi	serine/threonine protein kinase 6	0.0647	0.7953	0.7623
Onchocerca volvulus	Tyrosine kinase homolog	0.0305	0.1935	0.0302
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0757	0.9907	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TK/Met protein kinase	0.0305	0.1935	0.1954
Brugia malayi	Protein kinase domain containing protein	0.0757	0.9907	1
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Echinococcus granulosus	hypothetical protein	0.0453	0.4542	0.3232
Echinococcus granulosus	activin receptor type	0.031	0.2028	0.0115
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0647	0.7953	0.7549
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0305	0.1935	0.1954
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0757	0.9907	1
Brugia malayi	hypothetical protein	0.0305	0.1935	0.0302
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0757	0.9907	0.9885
Loa Loa (eye worm)	TK/FAK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0381	0.3281	0.3312
Brugia malayi	SH2 domain containing protein	0.0757	0.9907	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0453	0.4542	0.4584
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.031	0.2028	0.0117
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0305	0.1935	0.1954
Echinococcus granulosus	tyrosine protein kinase Srms	0.0757	0.9907	0.9885
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Onchocerca volvulus		0.0757	0.9907	1
Brugia malayi	Protein kinase domain containing protein	0.0757	0.9907	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0305	0.1935	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0757	0.9907	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0453	0.4542	0.3232
Trichomonas vaginalis	AGC family protein kinase	0.0647	0.7953	1
Echinococcus granulosus	acetylcholinesterase	0.0332	0.2408	0.0586
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.2028	0.0155
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Onchocerca volvulus		0.0305	0.1935	0.0302
Brugia malayi	C-terminal src kinase protein 1	0.0305	0.1935	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0332	0.2408	0.2431
Echinococcus multilocularis	tensin	0.0453	0.4542	0.3269
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0332	0.2408	0.0593
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0305	0.1935	0.0302
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0453	0.4542	0.4584
Echinococcus multilocularis	signal transduction protein lnk realted	0.0453	0.4542	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Onchocerca volvulus		0.0453	0.4542	0.3473
Brugia malayi	Furin-like cysteine rich region family protein	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0453	0.4542	0.4584
Echinococcus granulosus	SH2 motif	0.0453	0.4542	0.3232
Echinococcus multilocularis	NCK adaptor protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	AUR protein kinase	0.0647	0.7953	0.8028
Onchocerca volvulus		0.0757	0.9907	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0305	0.1935	0.1954
Onchocerca volvulus		0.0453	0.4542	0.3473
Entamoeba histolytica	protein kinase domain containing protein	0.0647	0.7953	0.7549
Brugia malayi	RhoGAP domain containing protein	0.0453	0.4542	0.3473
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0453	0.4542	0.3232
Brugia malayi	Protein kinase domain containing protein	0.0757	0.9907	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0453	0.4542	0.3232
Echinococcus granulosus	tyrosine kinase	0.0757	0.9907	0.9885
Entamoeba histolytica	protein kinase, putative	0.0647	0.7953	0.7549
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0305	0.1935	0.1954
Schistosoma mansoni	serine/threonine protein kinase	0.0647	0.7953	0.7549
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0305	0.1935	0.0302
Entamoeba histolytica	protein kinase, putative	0.0458	0.4635	0.3386
Loa Loa (eye worm)	TK/CSK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0305	0.1935	0.1954
Echinococcus multilocularis	acetylcholinesterase	0.0332	0.2408	0.0593
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0453	0.4542	0.3269
Trichomonas vaginalis	AGC family protein kinase	0.0647	0.7953	1
Onchocerca volvulus		0.0757	0.9907	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0453	0.4542	0.3232
Schistosoma mansoni	adapter molecule crk	0.0453	0.4542	0.3269
Schistosoma mansoni	growth factor receptor-bound protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Echinococcus granulosus	aurora kinase A	0.0647	0.7953	0.7462
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0453	0.4542	0.3232
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0757	0.9907	0.9885
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0381	0.3281	0.2236
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0647	0.7953	0.7462
Loa Loa (eye worm)	SRC-1	0.0757	0.9907	1
Onchocerca volvulus		0.0305	0.1935	0.0302
Echinococcus granulosus	N chimaerin	0.0453	0.4542	0.3232
Schistosoma mansoni	protein kinase	0.0647	0.7953	0.7549
Giardia lamblia	Aurora kinase	0.0647	0.7953	1
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.031	0.2028	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Echinococcus multilocularis	SHC transforming protein 3	0.0453	0.4542	0.3269
Schistosoma mansoni	shc transforming protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0757	0.9907	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0305	0.1935	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0453	0.4542	0.3232
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0453	0.4542	0.3473
Entamoeba histolytica	SH2 domain containing protein	0.0453	0.4542	0.3269
Brugia malayi	Tyrosine-protein kinase PR2	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK protein kinase	0.0757	0.9907	1
Brugia malayi	SH2 domain containing protein	0.0453	0.4542	0.3473
Schistosoma mansoni	tensin-related	0.0453	0.4542	0.3269
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0305	0.1935	0.0302
Brugia malayi	Guanylyl cyclase protein 23	0.0305	0.1935	0.0302
Brugia malayi	SRC-1	0.0757	0.9907	1
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Onchocerca volvulus		0.0453	0.4542	0.3473
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4542	0.4584
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Entamoeba histolytica	protein kinase , putative	0.0647	0.7953	0.7549
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0647	0.7953	0.7549
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0453	0.4542	0.3232
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Onchocerca volvulus		0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK/ACK protein kinase	0.0305	0.1935	0.1954
Schistosoma mansoni	protein kinase	0.031	0.2028	0.0117
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Loa Loa (eye worm)	TK/FER protein kinase	0.0757	0.9907	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0453	0.4542	0.3232
Brugia malayi	Variant SH3 domain containing protein	0.0453	0.4542	0.3473
Onchocerca volvulus		0.0757	0.9907	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0381	0.3281	0.1939
Schistosoma mansoni	tyrosine kinase	0.0757	0.9907	1
Echinococcus multilocularis	tyrosine kinase	0.0757	0.9907	1
Brugia malayi	protein-tyrosine kinase	0.0757	0.9907	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0757	0.9907	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0757	0.9907	0.9885
Echinococcus granulosus	acetylcholinesterase	0.0332	0.2408	0.0586
Echinococcus multilocularis	acetylcholinesterase	0.0332	0.2408	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0757	0.9907	1
Schistosoma mansoni	GTPase activating protein	0.0453	0.4542	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0332	0.2408	0.2431
Loa Loa (eye worm)	STAT protein	0.0453	0.4542	0.4584
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0757	0.9907	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0647	0.7953	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0305	0.1935	0.1954
Echinococcus granulosus	tyrosine protein kinase shark	0.0757	0.9907	0.9885
Leishmania major	C-8 sterol isomerase-like protein	0.0381	0.3281	0.2236
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0453	0.4542	0.3473
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.031	0.2028	0.0155
Loa Loa (eye worm)	TK protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.1687	0.1703
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0757	0.9907	0.9885
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0757	0.9907	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0305	0.1935	0.1954
Loa Loa (eye worm)	acetylcholinesterase 1	0.0332	0.2408	0.2431
Schistosoma mansoni	vav2	0.0453	0.4542	0.3269
Brugia malayi	Protein kinase domain containing protein	0.0305	0.1935	0.0302
Onchocerca volvulus		0.0305	0.1935	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1935	0.1954
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0757	0.9907	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0757	0.9907	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 11.8 uM	PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2354376

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1754621