Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0898 | 0.0154 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1096 | 0.3516 | 0.5422 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0898 | 0.0154 | 0.5 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0898 | 0.0154 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0898 | 0.0154 | 0.5 |
Onchocerca volvulus | 0.1478 | 1 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0898 | 0.0154 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.1478 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0898 | 0.0154 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.1478 | 1 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0898 | 0.0154 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1271 | 0.6484 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0898 | 0.0154 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0898 | 0.0154 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0898 | 0.0154 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0898 | 0.0154 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0898 | 0.0154 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.