Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.0455 | 1 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.029 | 0.4346 | 0.5 |
Leishmania major | ferric reductase, putative | 0.029 | 0.4346 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.029 | 0.4346 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0455 | 1 | 1 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.029 | 0.4346 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of IFN-gamma-induced STAT1 (unknown origin) at 10 uM | ChEMBL. | 23434226 | |
Inhibition (functional) | = 16.4 % | Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability at 10 uM | ChEMBL. | 23434226 |
Inhibition (binding) | = 20.21 % | Inhibition of IL-6-induced STAT3 pathway in human HepG2 cells at 10 uM by luciferase reporter gene assay | ChEMBL. | 23434226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.