Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.012 | 0.5066 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.012 | 0.5066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5066 | 0.5066 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.012 | 0.5066 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.012 | 0.5066 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.012 | 0.5066 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.012 | 0.5066 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.012 | 0.5066 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.012 | 0.5066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.012 | 0.5066 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.012 | 0.5066 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.012 | 0.5066 | 0.5066 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.012 | 0.5066 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.012 | 0.5066 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.012 | 0.5066 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.012 | 0.5066 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.012 | 0.5066 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.012 | 0.5066 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.012 | 0.5066 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.012 | 0.5066 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.012 | 0.5066 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.012 | 0.5066 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.012 | 0.5066 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.