Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1165 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.0445 | 0.0618 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.0445 | 0.3817 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.1728 | 0.5 |
Echinococcus granulosus | geminin | 0.017 | 0.1165 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0337 | 0.255 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0445 | 0.2989 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.0445 | 0.3817 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0337 | 0.255 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.0445 | 0.0445 | |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1165 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1488 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0896 | 0.7201 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0337 | 0.255 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0337 | 0.255 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0337 | 0.255 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0337 | 0.255 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 0.1165 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0337 | 0.255 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.0445 | 0.3817 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0337 | 0.255 | 0.5 |
Onchocerca volvulus | 0.0238 | 0.1728 | 0.1728 | |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1488 | 0.2066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC40 (functional) | = 11.81 uM | PubChem BioAssay. HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.