Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0689 | 0.4422 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0689 | 0.4422 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0689 | 0.4422 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1192 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0689 | 0.4422 | 0.5 |
Onchocerca volvulus | 0.0291 | 0 | 0.5 | |
Leishmania major | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0689 | 0.4422 | 1 |
Leishmania major | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0689 | 0.4422 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1192 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1192 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0689 | 0.4422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1192 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0689 | 0.4422 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0689 | 0.4422 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0689 | 0.4422 | 0.4422 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0689 | 0.4422 | 0.4422 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 0.4422 | 0.4422 |
Brugia malayi | Histone deacetylase 1 | 0.0689 | 0.4422 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0689 | 0.4422 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0689 | 0.4422 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0689 | 0.4422 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0689 | 0.4422 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0689 | 0.4422 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0689 | 0.4422 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0689 | 0.4422 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0689 | 0.4422 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0689 | 0.4422 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 10.86 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.