Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | MAPEG family protein | 0.0453 | 0.8299 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0453 | 0.8299 | 0.8299 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0477 | 1 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0453 | 0.8299 | 0.8299 |
Schistosoma mansoni | lipoxygenase | 0.0477 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (binding) | = 0.4 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as cleavage of S-2403 to colored product p-nitroaniline at 50 uM after 2 hrs relative to control | ChEMBL. | 23433668 |
T/C (binding) | = 0.84 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as cleavage of S-2403 to colored product p-nitroaniline at 5 uM after 2 hrs relative to control | ChEMBL. | 23433668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.