Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0839 | 0.0828 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.027 | 0.0258 |
Trypanosoma cruzi | casein kinase, putative | 0.1538 | 1 | 1 |
Echinococcus granulosus | casein kinase I delta | 0.1538 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0839 | 0.0828 |
Echinococcus multilocularis | casein kinase I delta | 0.1538 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.1538 | 1 | 1 |
Leishmania major | casein kinase, putative | 0.1538 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1538 | 1 | 1 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.1538 | 1 | 1 |
Echinococcus granulosus | casein kinase i | 0.1538 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.1538 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.027 | 0.0258 |
Echinococcus multilocularis | casein kinase I delta | 0.1538 | 1 | 1 |
Plasmodium falciparum | casein kinase 1 | 0.1538 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.1538 | 1 | 1 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.1538 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0277 | 0.0277 |
Trichomonas vaginalis | CK1 family protein kinase | 0.1538 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase I alpha | 0.1538 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0012 | 0.0012 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0277 | 0.0265 |
Echinococcus multilocularis | casein kinase I alpha | 0.1538 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0277 | 0.0265 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0839 | 0.0828 |
Echinococcus multilocularis | casein kinase i | 0.1538 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0839 | 0.0828 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0839 | 0.0839 |
Brugia malayi | casein kinase I | 0.1538 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0277 | 0.0265 |
Trichomonas vaginalis | CK1 family protein kinase | 0.1538 | 1 | 0.5 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.1538 | 1 | 1 |
Echinococcus granulosus | casein kinase I delta | 0.1538 | 1 | 1 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.1538 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.1538 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0277 | 0.0265 |
Entamoeba histolytica | casein kinase 1, putative | 0.1538 | 1 | 0.5 |
Onchocerca volvulus | 0.1538 | 1 | 1 | |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.1538 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.1538 | 1 | 1 |
Trichomonas vaginalis | CK1 family protein kinase | 0.1538 | 1 | 0.5 |
Echinococcus granulosus | casein kinase I alpha | 0.1538 | 1 | 1 |
Echinococcus granulosus | casein kinase I alpha | 0.1538 | 1 | 1 |
Toxoplasma gondii | casein kinase I | 0.1538 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.027 | 0.0258 |
Echinococcus multilocularis | casein kinase I alpha | 0.1538 | 1 | 1 |
Trypanosoma cruzi | casein kinase, putative | 0.1538 | 1 | 1 |
Plasmodium vivax | casein kinase 1, putative | 0.1538 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase, putative | 0.1538 | 1 | 1 |
Echinococcus granulosus | casein kinase I alpha | 0.1538 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 258 nM | Inhibition of human wild type GST-tagged EGFR kinase domain expressed in Sf9 cells by luminescence assay | ChEMBL. | 23611691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.