Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0262 | 0.0391 | 0.1531 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0353 | 0.0657 | 0.0521 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0892 | 0.2226 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2054 | 0.561 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0892 | 0.2226 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0262 | 0.0391 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 0.1358 | 0.5992 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0262 | 0.0391 | 0.0939 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.3561 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0353 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0353 | 0.0657 | 0.0382 |
Brugia malayi | Probable DNA topoisomerase II | 0.0892 | 0.2226 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0892 | 0.2226 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0892 | 0.2226 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.3561 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0353 | 0.0657 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0593 | 0.1358 | 0.5992 |
Brugia malayi | hypothetical protein | 0.016 | 0.0096 | 0.0167 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0892 | 0.2226 | 0.3589 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.063 | 0.1464 | 0.2056 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0353 | 0.0657 | 0.0277 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.3561 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.3561 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.3561 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2054 | 0.561 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.3561 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0777 | 0.1892 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0353 | 0.0657 | 0.0277 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0892 | 0.2226 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0262 | 0.0391 | 0.1531 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1162 | 0.3014 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2054 | 0.561 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0892 | 0.2226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0096 | 0.0167 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0892 | 0.2226 | 0.191 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0892 | 0.2226 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0892 | 0.2226 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2399 | 0.6616 | 0.6616 |
Leishmania major | DNA topoisomerase ii | 0.063 | 0.1464 | 0.2056 |
Schistosoma mansoni | DNA topoisomerase II | 0.0892 | 0.2226 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0262 | 0.0391 | 0.1531 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0262 | 0.0391 | 0.1531 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.063 | 0.1464 | 0.2056 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2017 | 0.5504 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.063 | 0.1464 | 0.2056 |
Brugia malayi | DNA topoisomerase III | 0.0262 | 0.0391 | 0.1531 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.063 | 0.1464 | 0.2056 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0353 | 0.0657 | 0.0277 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0892 | 0.2226 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0892 | 0.2226 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0892 | 0.2226 | 0.191 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2054 | 0.561 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0353 | 0.0657 | 0.0277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 4 10'-5M | Cytotoxicity against human MT2 cells by XTT assay | ChEMBL. | 23434230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.