Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0501 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0501 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0501 | 0.5 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0501 | 0.5 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0501 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0501 | 0.5 | 0.5 | |
Onchocerca volvulus | Deterin homolog | 0.0501 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0501 | 0.5 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0501 | 0.5 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0501 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth inhibition (functional) | = 25 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
Growth inhibition (functional) | = 25 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Aspergillus fumigatus (AF-27) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Sporothrix schenck ii (SS-1) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Trichophyton mentagrophytes (A-280) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.