Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0597 | 0.1135 | 0.1135 |
Onchocerca volvulus | 0.144 | 1 | 1 | |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.144 | 1 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.144 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.144 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.144 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.144 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.144 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.144 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.144 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0597 | 0.1135 | 0.1135 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Binding affinity to TYRO3 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to TYRO3 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MET (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MET (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to AXL (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to AXL (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to non phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 2 % | Binding affinity to phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 8 % | Binding affinity to MER (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 16 % | Binding affinity to MER (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 21 % | Binding affinity to non phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
GI (functional) | < 10 % | Growth inhibition of human PC3 cells at 10 uM after 72 hrs by MTT assay relative to control | ChEMBL. | 22749189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.