Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0013 | 0.00000010478 | 0.00000010582 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0015 | 0.0009 | 0.0009 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Toxoplasma gondii | transporter, cation channel family protein | 0.0013 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0015 | 0.0009 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0013 | 0.00000010478 | 0.00000010478 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.1516 | 0.9991 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0015 | 0.0009 | 0.0009 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0013 | 0.00000010478 | 0.00000010487 |
Echinococcus multilocularis | ankyrin repeat protein | 0.1502 | 0.9902 | 0.9902 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0009 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0013 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0013 | 0.00000010478 | 0.00000010582 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.00000010478 | 0.0001 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0015 | 0.0009 | 0.0009 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0015 | 0.0009 | 0.0009 |
Toxoplasma gondii | hypothetical protein | 0.0013 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.1502 | 0.9902 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0013 | 0 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0015 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.00000010478 | 0.0001 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.1502 | 0.9902 | 0.991 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 94.94 % | Inhibition of human 15-LOX-1 assessed as reduction in conversion of linoleic acid to 13(S)-HpODE by measuring residual activity at 50 uM incubated for 10 mins followed by linoleic acid addition by UV-absorbance analysis relative to control | LITERATURE. | 27477687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.