Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SET domain-containing protein | 0.2427 | 0.5 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.2427 | 0.5 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.2427 | 0.5 | 0.5 |
Schistosoma mansoni | enhancer of zeste ezh | 0.2427 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 5.88 uM | Cytotoxicity against mock-infected human MT4 cells assessed as cell viability after 5 days by MTT assay | ChEMBL. | 23415090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.