Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.097 | 1 | 0.5 |
Onchocerca volvulus | 0.097 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.017 | 0.0093 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0449 | 0.3551 | 0.3551 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3551 | 0.3551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.097 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.3551 | 0.3551 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.097 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.097 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.017 | 0.0093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.097 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.097 | 1 | 0.5 |
Onchocerca volvulus | 0.0287 | 0.154 | 0.154 | |
Toxoplasma gondii | kringle domain-containing protein | 0.097 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0162 | 0 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.097 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0449 | 0.3551 | 0.3551 |
Brugia malayi | Kringle domain containing protein | 0.097 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Onchocerca volvulus | 0.0449 | 0.3551 | 0.3551 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.0093 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.017 | 0.0093 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.097 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0449 | 0.3551 | 0.3551 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.097 | 1 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.017 | 0.0093 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (binding) | = 0.29 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as cleavage of S-2403 to colored product p-nitroaniline at 50 uM after 2 hrs relative to control | ChEMBL. | 23433668 |
T/C (binding) | = 0.47 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as cleavage of S-2403 to colored product p-nitroaniline at 5 uM after 2 hrs relative to control | ChEMBL. | 23433668 |
T1/2 (ADMET) | = 6.4 min | Half life in mouse liver microsomes at 0.5 to 1 uM by LC-MS/MS analysis | ChEMBL. | 23433668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.