Detailed information for compound 1760855

Basic information

Technical information
  • TDR Targets ID: 1760855
  • Name: 2-amino-5-(1,3-dihydro-2-benzofuran-5-yl)-4-m ethylthiophene-3-carbonitrile
  • MW: 256.323 | Formula: C14H12N2OS
  • H donors: 1 H acceptors: 1 LogP: 2.77 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)sc(c1C)c1ccc2c(c1)COC2
  • InChi: 1S/C14H12N2OS/c1-8-12(5-15)14(16)18-13(8)9-2-3-10-6-17-7-11(10)4-9/h2-4H,6-7,16H2,1H3
  • InChiKey: DAUJMWLIWGLBPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-5-(1,3-dihydroisobenzofuran-5-yl)-4-methyl-thiophene-3-carbonitrile
  • 2-amino-5-(1,3-dihydroisobenzofuran-5-yl)-4-methyl-3-thiophenecarbonitrile
  • 2-amino-5-(1,3-dihydro-2-benzofuran-5-yl)-4-methyl-thiophene-3-carbonitrile
  • NSC302961

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Protein 21.1 0.0966 0 0.5
Schistosoma mansoni tensin-related 0.1444 0.3309 0.331
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Echinococcus multilocularis SH2 domain containing protein 7 0.1444 0.3309 0.331
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0966 0.0003 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1444 0.3309 0.331
Brugia malayi cytokine inducible SH2-containing protein 5 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Schistosoma mansoni growth factor receptor-bound protein 0.1444 0.3309 0.331
Brugia malayi Variant SH3 domain containing protein 0.1444 0.3309 0.331
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.241 0.9997 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.241 0.9997 0.9997
Entamoeba histolytica protein kinase domain containing protein 0.0966 0.0003 0.0003
Schistosoma mansoni tensin 0.1444 0.3309 0.331
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0966 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Echinococcus granulosus activin receptor type 0.0966 0.0003 0.0003
Echinococcus granulosus growth factor receptor bound protein 2 0.1444 0.3309 0.3309
Echinococcus granulosus tyrosine protein kinase Src42A 0.241 0.9997 0.9997
Schistosoma mansoni tensin-related 0.1444 0.3309 0.331
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Onchocerca volvulus 0.1444 0.3309 0.331
Brugia malayi Protein kinase domain containing protein 0.241 0.9997 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1444 0.3309 0.331
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Entamoeba histolytica SH2 domain containing protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) STAT protein 0.1444 0.3309 0.331
Echinococcus granulosus NCK adaptor protein 0.1444 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1444 0.3309 0.331
Entamoeba histolytica SH2-protein kinase domain containing protein 0.241 0.9997 1
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Echinococcus granulosus N chimaerin 0.1444 0.3309 0.3309
Schistosoma mansoni hypothetical protein 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.241 0.9997 1
Echinococcus multilocularis SH2 motif 0.1444 0.3309 0.331
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.241 0.9997 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.241 0.9997 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1444 0.3309 0.331
Brugia malayi tRNA modification GTPase TrmE family protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.1444 0.3309 0.331
Brugia malayi hypothetical protein 0.1444 0.3309 0.331
Echinococcus granulosus c src tyrosine kinase 0.241 0.9997 0.9997
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni adapter molecule crk 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase Fyn 0.241 0.9997 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1444 0.3309 0.331
Brugia malayi RhoGAP domain containing protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Onchocerca volvulus 0.241 0.9997 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.241 0.9997 0.9997
Echinococcus granulosus tensin 0.1444 0.3309 0.3309
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1444 0.3309 0.3309
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1444 0.3309 0.331
Echinococcus granulosus tyrosine protein kinase Btk29A 0.241 0.9997 0.9997
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni GTPase activating protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0966 0.0003 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.241 0.9997 1
Schistosoma mansoni protein kinase 0.0966 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1444 0.3309 0.331
Schistosoma mansoni protein kinase 0.0966 0.0003 0.0003
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase ABL1 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Schistosoma mansoni SH2A 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni nck2/grb4 0.1444 0.3309 0.331
Trichomonas vaginalis STE family protein kinase 0.0966 0 0.5
Brugia malayi SRC-1 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1444 0.3309 0.331
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Schistosoma mansoni protein kinase 0.0966 0.0003 0.0003
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1444 0.3309 0.331
Brugia malayi Variant SH3 domain containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis activin receptor type 0.0966 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.241 0.9997 1
Brugia malayi Tyrosine-protein kinase abl-1 0.241 0.9997 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1444 0.3309 0.331
Loa Loa (eye worm) TK protein kinase 0.241 0.9997 1
Schistosoma mansoni growth factor receptor-bound protein 0.1444 0.3309 0.331
Schistosoma mansoni tensin 0.1444 0.3309 0.331
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0966 0.0003 1
Echinococcus granulosus signal transduction protein lnk realted 0.1444 0.3309 0.3309
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.241 0.9997 0.9997
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Giardia lamblia Kinase, NEK 0.0966 0 0.5
Brugia malayi protein-tyrosine kinase 0.241 0.9997 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0966 0 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.241 0.9997 0.9997
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1444 0.3309 0.3309
Trichomonas vaginalis TK family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.241 0.9997 0.9997
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine kinase 0.241 0.9997 0.9997
Trichomonas vaginalis protein kinase atn1, putative 0.0966 0 0.5
Echinococcus multilocularis N chimaerin 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Brugia malayi STAT protein, DNA binding domain containing protein 0.1444 0.3309 0.331
Onchocerca volvulus 0.241 0.9997 1
Echinococcus multilocularis tyrosine kinase 0.241 0.9997 1
Plasmodium falciparum protein kinase, putative 0.0966 0.0003 1
Trichomonas vaginalis CAMK family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Echinococcus granulosus tyrosine protein kinase Blk 0.241 0.9997 0.9997
Brugia malayi Variant SH3 domain containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.241 0.9997 1
Echinococcus multilocularis NCK adaptor protein 0.1444 0.3309 0.331
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1444 0.3309 0.331
Loa Loa (eye worm) SH2 domain-containing protein 0.1444 0.3309 0.331
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.241 0.9997 1
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1444 0.3309 0.331
Brugia malayi Sex muscle abnormal protein 5 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.241 0.9997 0.9997
Echinococcus multilocularis tyrosine protein kinase Srms 0.241 0.9997 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase Src64B 0.241 0.9997 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.241 0.9997 0.9997
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase Fyn 0.241 0.9997 1
Schistosoma mansoni vav2 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Onchocerca volvulus 0.1444 0.3309 0.331
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Brugia malayi Variant SH3 domain containing protein 0.1444 0.3309 0.331
Onchocerca volvulus 0.241 0.9997 1
Echinococcus granulosus SHC transforming protein 3 0.1444 0.3309 0.3309
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Echinococcus granulosus tyrosine protein kinase shark 0.241 0.9997 0.9997
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1444 0.3309 0.3309
Onchocerca volvulus 0.241 0.9997 1
Echinococcus multilocularis SH2 motif 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus SH2 motif 0.1444 0.3309 0.3309
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1444 0.3309 0.331
Brugia malayi hypothetical protein 0.241 0.9997 1
Onchocerca volvulus 0.1444 0.3309 0.331
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Brugia malayi SH2 domain containing protein 0.241 0.9997 1
Schistosoma mansoni tensin 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni hypothetical protein 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0966 0.0003 0.0003
Schistosoma mansoni signal transduction protein lnk-related 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Leishmania major protein kinase, putative 0.0966 0.0003 1
Giardia lamblia Kinase 0.0966 0 0.5
Brugia malayi Tensin 0.1444 0.3309 0.331
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1444 0.3311 0.3312
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1444 0.3309 0.331
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni shc transforming protein 0.1444 0.3309 0.331
Echinococcus granulosus tyrosine protein kinase Src42A 0.1444 0.3309 0.3309
Echinococcus multilocularis tensin 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.241 0.9997 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.241 0.9997 0.9997
Loa Loa (eye worm) SH2 domain-containing protein 0.1444 0.3309 0.331
Echinococcus multilocularis SHC transforming protein 3 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.241 0.9997 1
Loa Loa (eye worm) hypothetical protein 0.1444 0.3309 0.331
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.241 0.9997 0.9997
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1444 0.3309 0.3309
Echinococcus multilocularis c src tyrosine kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1444 0.3309 0.331
Onchocerca volvulus 0.1444 0.3309 0.331
Echinococcus multilocularis SH2 motif 0.1444 0.3309 0.331
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1444 0.3309 0.331
Loa Loa (eye worm) SRC-1 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus SH2 motif 0.1444 0.3309 0.3309
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0966 0.0003 1
Onchocerca volvulus 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Schistosoma mansoni tyrosine kinase 0.241 0.9997 1
Echinococcus granulosus expressed conserved protein 0.1444 0.3309 0.3309
Schistosoma mansoni suppressor of cytokine signaling 0.1444 0.3309 0.331
Echinococcus multilocularis tyrosine protein kinase Blk 0.241 0.9997 1
Echinococcus multilocularis signal transduction protein lnk realted 0.1444 0.3309 0.331
Echinococcus granulosus SH2 domain containing adapter protein F 0.1444 0.3309 0.3309
Echinococcus granulosus suppressor of cytokine signaling 6 0.1444 0.3309 0.3309
Giardia lamblia Kinase, NEK 0.0966 0 0.5
Brugia malayi Protein kinase domain containing protein 0.241 0.9997 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0966 0 0.5
Echinococcus multilocularis tensin 0.1444 0.3309 0.331
Brugia malayi Protein kinase domain containing protein 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1444 0.3309 0.3309
Onchocerca volvulus 0.1444 0.3309 0.331
Trichomonas vaginalis AGC family protein kinase 0.0966 0 0.5
Plasmodium vivax protein kinase, putative 0.0966 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.241 0.9997 1
Brugia malayi SH2 domain containing protein 0.1444 0.3309 0.331
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1444 0.3309 0.331
Echinococcus granulosus suppressor of cytokine signaling 7 0.1444 0.3309 0.3309
Echinococcus granulosus tyrosine kinase 0.241 0.9997 0.9997
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.1444 0.3309 0.331
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Loa Loa (eye worm) TK/ABL protein kinase 0.241 0.9997 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.241 0.9997 1
Echinococcus granulosus SH2 domain containing protein 7 0.1444 0.3309 0.3309
Loa Loa (eye worm) TK/FER protein kinase 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.241 0.9997 0.9997
Echinococcus multilocularis 0.1444 0.3309 0.331
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Onchocerca volvulus 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Echinococcus granulosus hypothetical protein 0.1444 0.3309 0.3309
Onchocerca volvulus 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Trypanosoma brucei protein kinase, putative 0.0966 0.0003 1
Trichomonas vaginalis conserved hypothetical protein 0.0966 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5
Entamoeba histolytica protein kinase, putative 0.1444 0.3311 0.3312
Loa Loa (eye worm) hypothetical protein 0.241 0.9997 1
Trichomonas vaginalis TKL family protein kinase 0.0966 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.44 uM Inhibition of human IKKbeta using GST-IkappaBalpha as substrate ChEMBL. 23501112
Inhibition (binding) = 92.4 % Inhibition of human IKKbeta using GST-IkappaBalpha as substrate at 10 uM ChEMBL. 23501112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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