TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.395 | Formula: C19H21FN4
H donors: 1 H acceptors: 1 LogP: 2.41 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cncc(c1)c1cccc(c1)[C@@]1(C)N=C([C@H]2N1CCCC2)N
InChi: 1S/C19H21FN4/c1-19(23-18(21)17-7-2-3-8-24(17)19)15-6-4-5-13(9-15)14-10-16(20)12-22-11-14/h4-6,9-12,17H,2-3,7-8H2,1H3,(H2,21,23)/t17-,19-/m0/s1
InChiKey: LXQPUHUACOXCSI-HKUYNNGSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	beta-site APP-cleaving enzyme 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	memapsin-2 (A01 family)	Get druggable targets OG5_135830	All targets in OG5_135830
Schistosoma japonicum	ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative	Get druggable targets OG5_135830	All targets in OG5_135830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin VII	beta-site APP-cleaving enzyme 1	401 aa	352 aa	21.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	SHC transforming protein 3	0.0126	0.0965	0.3331
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0126	0.0965	0.3331
Onchocerca volvulus		0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	tensin	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis		0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0211	0.2897	1
Schistosoma mansoni	tensin	0.0126	0.0965	0.0965
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0211	0.2897	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	hypothetical protein	0.0126	0.0965	0.0965
Brugia malayi	Tensin	0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine kinase	0.0211	0.2897	1
Onchocerca volvulus		0.0211	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0084	0	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0126	0.0965	0.3331
Onchocerca volvulus		0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0211	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Leishmania major	hypothetical protein, conserved	0.0084	0	0.5
Leishmania major	protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	vav2	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0211	0.2897	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0126	0.0965	0.3331
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0126	0.0965	0.3331
Schistosoma mansoni	adapter molecule crk	0.0126	0.0965	0.0965
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Brugia malayi	Variant SH3 domain containing protein	0.0126	0.0965	0.3331
Plasmodium vivax	protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0211	0.2897	1
Brugia malayi	Protein kinase domain containing protein	0.0211	0.2897	1
Loa Loa (eye worm)	SRC-1	0.0211	0.2897	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0084	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0105	0.0482	0.1664
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	SRC-1	0.0211	0.2897	1
Schistosoma mansoni	tensin-related	0.0126	0.0965	0.0965
Echinococcus multilocularis	NCK adaptor protein	0.0126	0.0965	0.3331
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	signal transduction protein lnk realted	0.0126	0.0965	0.3331
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	AGC family protein kinase	0.0084	0	0.5
Onchocerca volvulus		0.0211	0.2897	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0211	0.2897	1
Onchocerca volvulus		0.0126	0.0965	0.3331
Schistosoma mansoni	growth factor receptor-bound protein	0.0126	0.0965	0.0965
Echinococcus multilocularis	SH2 motif	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0126	0.0965	0.0965
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0482	0.1664
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0211	0.2897	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Brugia malayi	hypothetical protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0211	0.2897	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0211	0.2897	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0211	0.2897	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0084	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Toxoplasma gondii	PAN domain-containing protein	0.0352	0.6139	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Onchocerca volvulus		0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Onchocerca volvulus		0.0211	0.2897	1
Onchocerca volvulus		0.0211	0.2897	1
Plasmodium falciparum	protein kinase, putative	0.0084	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0126	0.0965	0.3331
Schistosoma mansoni	tensin-related	0.0126	0.0965	0.0965
Giardia lamblia	Kinase, NEK	0.0084	0	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0211	0.2897	1
Echinococcus granulosus	tensin	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	hypothetical protein	0.0211	0.2897	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	SH2 motif	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0126	0.0965	0.3331
Onchocerca volvulus		0.0095	0.0248	0.0855
Echinococcus granulosus	SH2 motif	0.0126	0.0965	0.3331
Giardia lamblia	Kinase	0.0084	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0211	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Giardia lamblia	Protein 21.1	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0126	0.0965	0.0965
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0211	0.2897	1
Trichomonas vaginalis	TK family protein kinase	0.0084	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0126	0.0965	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Brugia malayi	Protein kinase domain containing protein	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0126	0.0965	0.3331
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Schistosoma mansoni	shc transforming protein	0.0126	0.0965	0.0965
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0211	0.2897	1
Echinococcus granulosus	hypothetical protein	0.0126	0.0965	0.3331
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	N chimaerin	0.0126	0.0965	0.3331
Trichomonas vaginalis	STE family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Schistosoma mansoni	hypothetical protein	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Schistosoma mansoni	SH2A	0.0126	0.0965	0.0965
Schistosoma mansoni	tensin	0.0126	0.0965	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0211	0.2897	1
Schistosoma mansoni	nck2/grb4	0.0126	0.0965	0.0965
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Toxoplasma gondii	PAN domain-containing protein	0.0352	0.6139	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0126	0.0965	0.0965
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0211	0.2897	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Trypanosoma brucei	Pseudokinase, putative	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0126	0.0965	0.3331
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0211	0.2897	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0126	0.0965	0.3331
Brugia malayi	Protein kinase domain containing protein	0.0211	0.2897	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0126	0.0965	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	c src tyrosine kinase	0.0211	0.2897	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0126	0.0965	0.3331
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0211	0.2897	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0126	0.0965	0.3331
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0211	0.2897	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0126	0.0965	0.3331
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0211	0.2897	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0126	0.0965	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Brugia malayi	Sex muscle abnormal protein 5	0.0126	0.0965	0.3331
Giardia lamblia	Kinase, NEK	0.0084	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0126	0.0965	0.0965
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0211	0.2897	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0	0.5
Echinococcus multilocularis	N chimaerin	0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0211	0.2897	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.0965	0.3331
Plasmodium falciparum	protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0126	0.0965	0.3331
Trypanosoma cruzi	protein kinase, putative	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Brugia malayi	Variant SH3 domain containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0126	0.0965	0.3331
Loa Loa (eye worm)	STAT protein	0.0126	0.0965	0.3331
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0211	0.2897	1
Trypanosoma brucei	protein kinase, putative	0.0084	0	0.5
Echinococcus multilocularis	tensin	0.0126	0.0965	0.3331
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0126	0.0965	0.3331
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0211	0.2897	1
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0126	0.0965	0.3331
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0126	0.0965	0.3331
Trypanosoma cruzi	protein kinase, putative	0.0084	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0211	0.2897	1
Onchocerca volvulus		0.0211	0.2897	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0	0.5
Onchocerca volvulus		0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	protein kinase atn1, putative	0.0084	0	0.5
Leishmania major	protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Onchocerca volvulus		0.0126	0.0965	0.3331
Brugia malayi	RhoGAP domain containing protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0965	0.3331
Schistosoma mansoni	suppressor of cytokine signaling	0.0126	0.0965	0.0965
Brugia malayi	Tyrosine-protein kinase abl-1	0.0211	0.2897	1
Brugia malayi	Protein kinase domain containing protein	0.0211	0.2897	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0084	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0126	0.0965	0.3331
Plasmodium falciparum	protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Onchocerca volvulus		0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine kinase	0.0211	0.2897	1
Echinococcus multilocularis	SH2 motif	0.0126	0.0965	0.3331
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0084	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0126	0.0965	0.3331
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0211	0.2897	1
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Brugia malayi	SH2 domain containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	SHC transforming protein 3	0.0126	0.0965	0.3331
Echinococcus granulosus	NCK adaptor protein	0.0126	0.0965	0.3331
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0126	0.0965	0.0965
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0126	0.0965	0.3331
Schistosoma mansoni	tensin	0.0126	0.0965	0.0965
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Echinococcus granulosus	expressed conserved protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0211	0.2897	1
Echinococcus granulosus	SH2 motif	0.0126	0.0965	0.3331
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0211	0.2897	0.2897
Trichomonas vaginalis	TKL family protein kinase	0.0084	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0126	0.0965	0.3331
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0126	0.0965	0.3331
Schistosoma mansoni	tyrosine kinase	0.0211	0.2897	0.2897
Echinococcus granulosus	tyrosine protein kinase shark	0.0211	0.2897	1
Loa Loa (eye worm)	TK protein kinase	0.0211	0.2897	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0126	0.0965	0.3331
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0211	0.2897	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.5 uM	Inhibition of BACE1-mediated soluble APPbeta release in human SH-SY5Y cells after 16 hrs	ChEMBL.	23126626
IC50 (binding)	= 4 uM	Inhibition of human BACE1 (1-460) using CEVNLDAEFK as substrate preincubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRET assay	ChEMBL.	23126626

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2380452

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1761071