TDR Targets

Basic information

Technical information

TDR Targets ID: 1761752
Name: [6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3 ,4-dihydro-1H-isoquinolin-2-yl]-[3-(trifluoro methyl)phenyl]methanone
MW: 501.494 | Formula: C27H26F3NO5
H donors: 0 H acceptors: 1 LogP: 5.41 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2c(cc1OC)CCN(C2COc1ccc(cc1)OC)C(=O)c1cccc(c1)C(F)(F)F
InChi: 1S/C27H26F3NO5/c1-33-20-7-9-21(10-8-20)36-16-23-22-15-25(35-3)24(34-2)14-17(22)11-12-31(23)26(32)18-5-4-6-19(13-18)27(28,29)30/h4-10,13-15,23H,11-12,16H2,1-3H3
InChiKey: KWLDLGIOWAILFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Ionotropic glutamate receptor NMDA 1/2D	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate NMDA receptor; Grin1/Grin2c	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Drosophila melanogaster	NMDA receptor 2	Glutamate NMDA receptor; Grin1/Grin2c	938 aa	878 aa	27.4 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate NMDA receptor; Grin1/Grin2c	938 aa	979 aa	23.7 %
Schistosoma mansoni	glutamate receptor NMDA	Glutamate NMDA receptor; Grin1/Grin2c	938 aa	933 aa	39.1 %
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	Glutamate NMDA receptor; Grin1/Grin2c	938 aa	822 aa	23.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0128	0.2157	0.5
Echinococcus granulosus	expressed conserved protein	0.0204	0.5081	0.5081
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0204	0.5081	0.5081
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0204	0.5081	0.5081
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Trypanosoma cruzi	protein kinase, putative	0.0128	0.2157	0.5
Brugia malayi	Tensin	0.0204	0.5081	0.3728
Echinococcus granulosus	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Brugia malayi	hypothetical protein	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0204	0.5081	0.3728
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0128	0.2157	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0204	0.5081	0.3728
Loa Loa (eye worm)	SH2 domain-containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	tyrosine protein kinase HCK	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Schistosoma mansoni	vav2	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0332	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0332	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0332	1	1
Onchocerca volvulus		0.0204	0.5081	0.3728
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0332	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0332	1	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Trypanosoma brucei	Pseudokinase, putative	0.0128	0.2157	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0332	1	1
Schistosoma mansoni	tensin-related	0.0204	0.5081	0.3728
Echinococcus granulosus	activated cdc42 kinase 1	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Schistosoma mansoni	SH2A	0.0204	0.5081	0.3728
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0128	0.2157	0.2157
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0332	1	1
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0128	0.2157	0.2157
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Plasmodium vivax	protein kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0128	0.2157	0.2157
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0128	0.2157	0.2157
Trypanosoma cruzi	protein kinase, putative	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0332	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine protein kinase Srms	0.0332	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0204	0.5081	0.5081
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0332	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0128	0.2157	0.2157
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0332	1	1
Brugia malayi	RhoGAP domain containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	SH2 domain containing protein 7	0.0204	0.5081	0.5081
Echinococcus granulosus	tyrosine kinase	0.0138	0.2554	0.2554
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Giardia lamblia	Kinase, NEK	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0332	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0204	0.5081	0.5081
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0204	0.5081	0.5081
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine kinase	0.0332	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TK family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	activin receptor type	0.0128	0.2157	0.2157
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0204	0.5081	0.3728
Onchocerca volvulus		0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	SHC transforming protein 3	0.0204	0.5081	0.5081
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0128	0.2157	0.2157
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0138	0.2554	0.2554
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Schistosoma mansoni	nck2/grb4	0.0204	0.5081	0.3728
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0128	0.2157	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0138	0.2554	0.0507
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0204	0.5081	0.5081
Schistosoma mansoni	suppressor of cytokine signaling	0.0204	0.5081	0.3728
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0128	0.2157	0.2157
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0128	0.2157	0.2157
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Echinococcus multilocularis	insulin receptor	0.0128	0.2157	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Brugia malayi	protein-tyrosine kinase	0.0332	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Leishmania major	hypothetical protein, conserved	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Onchocerca volvulus		0.0204	0.5081	0.3728
Onchocerca volvulus		0.0204	0.5081	0.3728
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0128	0.2157	0.2157
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Echinococcus multilocularis	tensin	0.0204	0.5081	0.5081
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0332	1	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus granulosus	SH2 motif	0.0204	0.5081	0.5081
Echinococcus granulosus	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Onchocerca volvulus		0.0332	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0128	0.2157	0.2157
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0204	0.5081	0.5081
Toxoplasma gondii	STE kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Echinococcus granulosus	insulin receptor	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0128	0.2157	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0138	0.2554	0.0507
Brugia malayi	hypothetical protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0128	0.2157	0.2157
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0204	0.5081	0.5081
Echinococcus granulosus	growth factor receptor bound protein 2	0.0204	0.5081	0.5081
Schistosoma mansoni	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0204	0.5081	0.5081
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Onchocerca volvulus		0.0332	1	1
Schistosoma mansoni	tyrosine kinase	0.0138	0.2554	0.0507
Echinococcus multilocularis	protein kinase	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tensin	0.0204	0.5081	0.5081
Schistosoma mansoni	tyrosine kinase	0.0138	0.2554	0.0507
Brugia malayi	Protein kinase domain containing protein	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0138	0.2554	0.0507
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine kinase	0.0332	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0332	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0332	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0204	0.5081	0.3728
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine kinase	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0128	0.2157	0.2157
Echinococcus multilocularis	N chimaerin	0.0204	0.5081	0.5081
Brugia malayi	Protein kinase domain containing protein	0.0332	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0138	0.2554	0.0507
Onchocerca volvulus		0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0332	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine protein kinase pr2	0.0128	0.2157	0.2157
Giardia lamblia	Kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Schistosoma mansoni	shc transforming protein	0.0204	0.5081	0.3728
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0128	0.2157	0.2157
Echinococcus multilocularis	heat shock protein 70	0.0128	0.2157	0.2157
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Leishmania major	protein kinase, putative	0.0128	0.2157	0.5
Giardia lamblia	Protein 21.1	0.0128	0.2157	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0204	0.5081	0.5081
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0204	0.5081	0.5081
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0128	0.2157	0.2157
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0204	0.5081	0.5081
Plasmodium falciparum	protein kinase, putative	0.0128	0.2157	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Brugia malayi	SRC-1	0.0332	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0128	0.2157	0.5
Brugia malayi	Protein kinase domain containing protein	0.0332	1	1
Schistosoma mansoni	tensin	0.0204	0.5081	0.3728
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0128	0.2157	0.2157
Echinococcus multilocularis	signal transduction protein lnk realted	0.0204	0.5081	0.5081
Trichomonas vaginalis	protein kinase atn1, putative	0.0128	0.2157	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0204	0.5081	0.3728
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Schistosoma mansoni	adapter molecule crk	0.0204	0.5081	0.3728
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Leishmania major	protein kinase, putative	0.0128	0.2157	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0128	0.2157	0.5
Loa Loa (eye worm)	TK protein kinase	0.0332	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0204	0.5081	0.5081
Loa Loa (eye worm)	STAT protein	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0204	0.5081	0.3728
Brugia malayi	Variant SH3 domain containing protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase	0.0128	0.2157	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0204	0.5081	0.3728
Schistosoma mansoni	suppressor of cytokine signaling	0.0204	0.5081	0.3728
Echinococcus granulosus	activin receptor type	0.0128	0.2157	0.2157
Schistosoma mansoni	tensin	0.0204	0.5081	0.3728
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0204	0.5081	0.5081
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0204	0.5081	0.3728
Loa Loa (eye worm)	SRC-1	0.0332	1	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0128	0.2157	0.5
Schistosoma mansoni	GTPase activating protein	0.0204	0.5081	0.3728
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Giardia lamblia	Kinase, NEK	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0332	1	1
Onchocerca volvulus		0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	SH2 motif	0.0204	0.5081	0.5081
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0128	0.2157	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	tyrosine protein kinase shark	0.0332	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0204	0.5081	0.5081
Echinococcus multilocularis	protein kinase	0.0128	0.2157	0.2157
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0332	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0204	0.5081	0.5081
Brugia malayi	Variant SH3 domain containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine protein kinase	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0128	0.2157	0.2157
Schistosoma mansoni	signal transduction protein lnk-related	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0204	0.5081	0.5081
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0332	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0332	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0204	0.5081	0.5081
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0204	0.5081	0.3728
Onchocerca volvulus		0.0332	1	1
Plasmodium falciparum	protein kinase, putative	0.0128	0.2157	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0128	0.2157	0.5
Echinococcus multilocularis	SH2 motif	0.0204	0.5081	0.5081
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0332	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0138	0.2554	0.2554
Loa Loa (eye worm)	SH2 domain-containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Echinococcus granulosus	N chimaerin	0.0204	0.5081	0.5081
Brugia malayi	Tyrosine-protein kinase abl-1	0.0332	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0128	0.2157	0.2157
Echinococcus multilocularis	epidermal growth factor receptor	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0332	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0138	0.2554	0.0507
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0128	0.2157	0.2157
Schistosoma mansoni	tensin-related	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0332	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0204	0.5081	0.5081
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0128	0.2157	0.2157
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine kinase	0.0138	0.2554	0.2554
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0204	0.5081	0.5081
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0128	0.2157	0.2157
Toxoplasma gondii	protein kinase	0.0128	0.2157	0.5
Onchocerca volvulus		0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	hypothetical protein	0.0204	0.5081	0.5081
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0332	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0128	0.2157	0.2157
Schistosoma mansoni	protein kinase	0.0138	0.2554	0.0507
Trichomonas vaginalis	CAMK family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	STE family protein kinase	0.0128	0.2157	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0204	0.5081	0.3728
Echinococcus multilocularis	SH2 motif	0.0204	0.5081	0.5081
Echinococcus granulosus	protein tyrosine kinase	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0332	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0128	0.2157	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase csk	0.0128	0.2157	0.2157
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0332	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0138	0.2554	0.0507
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	protein kinase	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Entamoeba histolytica	protein kinase, putative	0.0204	0.5081	0.3728
Loa Loa (eye worm)	hypothetical protein	0.0332	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0332	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0332	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0128	0.2157	0.5
Echinococcus granulosus	tensin	0.0204	0.5081	0.5081
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0204	0.5081	0.5081
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0204	0.5081	0.3728
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0128	0.2157	0.2157
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0332	1	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.5081	0.3728
Schistosoma mansoni	tensin	0.0204	0.5081	0.3728
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0138	0.2554	0.0507
Trypanosoma brucei	protein kinase, putative	0.0128	0.2157	0.5
Echinococcus multilocularis		0.0204	0.5081	0.5081
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0332	1	1
Schistosoma mansoni	tyrosine kinase	0.0332	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.2157	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0332	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Plasmodium falciparum	protein kinase, putative	0.0128	0.2157	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Echinococcus granulosus	NCK adaptor protein	0.0204	0.5081	0.5081
Schistosoma mansoni	hypothetical protein	0.0204	0.5081	0.3728
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0128	0.2157	0.2157
Brugia malayi	Protein kinase domain containing protein	0.0332	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0204	0.5081	0.3728
Loa Loa (eye worm)	TK/ABL protein kinase	0.0332	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0204	0.5081	0.3728
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0128	0.2157	0.2157
Echinococcus granulosus	SH2 motif	0.0204	0.5081	0.5081
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0332	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0128	0.2157	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0204	0.5081	0.5081
Echinococcus multilocularis	integrin linked protein kinase	0.0128	0.2157	0.2157
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.2157	0.5
Onchocerca volvulus		0.0332	1	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0128	0.2157	0.2157
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0204	0.5081	0.3728
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0128	0.2157	0.2157
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0204	0.5081	0.5081
Toxoplasma gondii	protein kinase domain-containing protein	0.0128	0.2157	0.5
Onchocerca volvulus		0.0138	0.2554	0.0507
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0204	0.5081	0.3728
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0128	0.2157	0.2157
Loa Loa (eye worm)	TK/FER protein kinase	0.0332	1	1
Onchocerca volvulus		0.0332	1	1
Brugia malayi	SH2 domain containing protein	0.0204	0.5081	0.3728

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 187 %	Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control	ChEMBL.	23627311
Activity (binding)	= 201 %	Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to glycine/glutamate	ChEMBL.	23627311
Activity (binding)	= 202 %	Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control	ChEMBL.	23627311
Activity (binding)	= 218 %	Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to glycine/glutamate	ChEMBL.	23627311
EC50 (binding)	= 2.4 uM	Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp technique	ChEMBL.	23627311
EC50 (binding)	= 2.4 uM	Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp technique	ChEMBL.	23627311

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2397211

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1761752