Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1299 | 0.8125 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.031 | 0 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.031 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.1299 | 0.8125 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.031 | 0 | 0.5 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.031 | 0 | 0.5 |
Onchocerca volvulus | 0.1299 | 0.8125 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -4.52 | Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme. | ChEMBL. | 11087569 |
IC50 (binding) | = -4.52 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 9526559 |
IC50 (binding) | = 30000 nM | In vitro inhibition of HIV-1 protease | ChEMBL. | 7830273 |
IC50 (binding) | = 30000 nM | In vitro inhibition of HIV-1 protease | ChEMBL. | 7830273 |
Log IC50 (binding) | = 4.52 | Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme. | ChEMBL. | 11087569 |
Log IC50 (binding) | = 4.52 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 9526559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.