Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 97 % | Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 23627311 |
Activity (binding) | = 99 % | Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assessed as potentiation of glycine/glutamate-induced activation at 10 uM by two-electrode voltage clamp technique relative to control | ChEMBL. | 23627311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.